Molecular epidemiology of a large community-based outbreak of hepatitis B in Bristol, UK

Monique I. Andersson; Nicola Low; Charles J. Irish; David Carrington; Richard Myers; Matthew Hickman; Chong-Gee Teo; Samreen Ijaz

doi:10.1016/j.jcv.2011.10.012

Molecular epidemiology of a large community-based outbreak of hepatitis B in Bristol, UK

Monique I. Andersson, Nicola Low, Charles J. Irish, David Carrington, Richard Myers, Matthew Hickman, Chong-Gee Teo, Samreen Ijaz

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Background: A large outbreak of hepatitis B virus (HBV) infection in the UK occurred between 2001 and 2005 in Bristol, UK.

Objectives: To identify HBV strains circulating amongst risk groups in the HBV outbreak cohort.

Study design: Cross-sectional study of acute HBV outbreak cases in Bristol.

Results: HBV sequences from sera of 95 of the 237 cases (40%) were characterised. The majority of cases (77%) were found to carry an HBV variant belonging to genotype D, designated HBVBV. Eighty-eight percent (36/41) of sequences from injection drug users were HBVBV as were 70% (19/27) from those with heterosexual intercourse as the primary identified risk factor. Of 15 sequences characterised from cases of pre-outbreak acute or chronic hepatitis B residing in Bristol, 40% also carried HBVBV; the earliest was from a case identified in 1994.

Conclusion: The findings from this study link the spread of HBVBV from injecting drug users to the general population through heterosexual intercourse during the outbreak. The molecular sequencing of specimens from this outbreak reports the emergence of HBVBV, a HBV strain circulating in Bristol and South West England, as the cause of one of the largest outbreaks of acute hepatitis B in the UK. (C) 2011 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	125-129
Number of pages	5
Journal	Journal of Clinical Virology
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/j.jcv.2011.10.012
Publication status	Published - Feb 2012

Bibliographical note

Keywords

Adult
Cohort Studies
Community-Acquired Infections
Cross-Sectional Studies
Disease Outbreaks
Female
Genotype
Great Britain
Hepatitis B
Hepatitis B virus
Humans
Male
Molecular Epidemiology
Phylogeny
Sexually Transmitted Diseases, Viral
Substance Abuse, Intravenous

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Molecular epidemiology of a large community-based outbreak of hepatitis B in Bristol, UK",

abstract = "Background: A large outbreak of hepatitis B virus (HBV) infection in the UK occurred between 2001 and 2005 in Bristol, UK.Objectives: To identify HBV strains circulating amongst risk groups in the HBV outbreak cohort.Study design: Cross-sectional study of acute HBV outbreak cases in Bristol.Results: HBV sequences from sera of 95 of the 237 cases (40%) were characterised. The majority of cases (77%) were found to carry an HBV variant belonging to genotype D, designated HBVBV. Eighty-eight percent (36/41) of sequences from injection drug users were HBVBV as were 70% (19/27) from those with heterosexual intercourse as the primary identified risk factor. Of 15 sequences characterised from cases of pre-outbreak acute or chronic hepatitis B residing in Bristol, 40% also carried HBVBV; the earliest was from a case identified in 1994.Conclusion: The findings from this study link the spread of HBVBV from injecting drug users to the general population through heterosexual intercourse during the outbreak. The molecular sequencing of specimens from this outbreak reports the emergence of HBVBV, a HBV strain circulating in Bristol and South West England, as the cause of one of the largest outbreaks of acute hepatitis B in the UK. (C) 2011 Elsevier B.V. All rights reserved.",

keywords = "Adult, Cohort Studies, Community-Acquired Infections, Cross-Sectional Studies, Disease Outbreaks, Female, Genotype, Great Britain, Hepatitis B, Hepatitis B virus, Humans, Male, Molecular Epidemiology, Phylogeny, Sexually Transmitted Diseases, Viral, Substance Abuse, Intravenous",

author = "Andersson, {Monique I.} and Nicola Low and Irish, {Charles J.} and David Carrington and Richard Myers and Matthew Hickman and Chong-Gee Teo and Samreen Ijaz",

year = "2012",

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doi = "10.1016/j.jcv.2011.10.012",

language = "English",

volume = "53",

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T1 - Molecular epidemiology of a large community-based outbreak of hepatitis B in Bristol, UK

AU - Andersson, Monique I.

AU - Low, Nicola

AU - Irish, Charles J.

AU - Carrington, David

AU - Myers, Richard

AU - Hickman, Matthew

AU - Teo, Chong-Gee

AU - Ijaz, Samreen

PY - 2012/2

Y1 - 2012/2

N2 - Background: A large outbreak of hepatitis B virus (HBV) infection in the UK occurred between 2001 and 2005 in Bristol, UK.Objectives: To identify HBV strains circulating amongst risk groups in the HBV outbreak cohort.Study design: Cross-sectional study of acute HBV outbreak cases in Bristol.Results: HBV sequences from sera of 95 of the 237 cases (40%) were characterised. The majority of cases (77%) were found to carry an HBV variant belonging to genotype D, designated HBVBV. Eighty-eight percent (36/41) of sequences from injection drug users were HBVBV as were 70% (19/27) from those with heterosexual intercourse as the primary identified risk factor. Of 15 sequences characterised from cases of pre-outbreak acute or chronic hepatitis B residing in Bristol, 40% also carried HBVBV; the earliest was from a case identified in 1994.Conclusion: The findings from this study link the spread of HBVBV from injecting drug users to the general population through heterosexual intercourse during the outbreak. The molecular sequencing of specimens from this outbreak reports the emergence of HBVBV, a HBV strain circulating in Bristol and South West England, as the cause of one of the largest outbreaks of acute hepatitis B in the UK. (C) 2011 Elsevier B.V. All rights reserved.

AB - Background: A large outbreak of hepatitis B virus (HBV) infection in the UK occurred between 2001 and 2005 in Bristol, UK.Objectives: To identify HBV strains circulating amongst risk groups in the HBV outbreak cohort.Study design: Cross-sectional study of acute HBV outbreak cases in Bristol.Results: HBV sequences from sera of 95 of the 237 cases (40%) were characterised. The majority of cases (77%) were found to carry an HBV variant belonging to genotype D, designated HBVBV. Eighty-eight percent (36/41) of sequences from injection drug users were HBVBV as were 70% (19/27) from those with heterosexual intercourse as the primary identified risk factor. Of 15 sequences characterised from cases of pre-outbreak acute or chronic hepatitis B residing in Bristol, 40% also carried HBVBV; the earliest was from a case identified in 1994.Conclusion: The findings from this study link the spread of HBVBV from injecting drug users to the general population through heterosexual intercourse during the outbreak. The molecular sequencing of specimens from this outbreak reports the emergence of HBVBV, a HBV strain circulating in Bristol and South West England, as the cause of one of the largest outbreaks of acute hepatitis B in the UK. (C) 2011 Elsevier B.V. All rights reserved.

KW - Adult

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KW - Cross-Sectional Studies

KW - Disease Outbreaks

KW - Female

KW - Genotype

KW - Great Britain

KW - Hepatitis B

KW - Hepatitis B virus

KW - Humans

KW - Male

KW - Molecular Epidemiology

KW - Phylogeny

KW - Sexually Transmitted Diseases, Viral

KW - Substance Abuse, Intravenous

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DO - 10.1016/j.jcv.2011.10.012

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JO - Journal of Clinical Virology

JF - Journal of Clinical Virology

IS - 2

ER -

Molecular epidemiology of a large community-based outbreak of hepatitis B in Bristol, UK

Abstract

Bibliographical note

Keywords

UN SDGs

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