Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model

Luis M B B Estronca, Joao C P Silva, Julio L Sampaio, Andrej Shevchenko, Paul Verkade, Alfin D N Vaz, Winchil L C Vaz, Otilia V Vieira

Research output: Contribution to journalArticle (Academic Journal)peer-review

15 Citations (Scopus)

Abstract

Atherosclerosis starts by lipid accumulation in the arterial intima and progresses into a chronic vascular inflammatory disease. A major atherogenic process is the formation of lipid-loaded macrophages in which a breakdown of the endolysomal pathway results in irreversible accumulation of cargo in the late endocytic compartments with a phenotype similar to several forms of lipidosis. Macrophages exposed to oxidized LDL exihibit this phenomenon in vitro and manifest an impaired degradation of internalized lipids and enhanced inflammatory stimulation. Identification of the specific chemical component(s) causing this phenotype has been elusive because of the chemical complexity of oxidized LDL.
Original languageEnglish
Pages (from-to)e34822
JournalPLoS ONE
Volume7
Issue number4
DOIs
Publication statusPublished - 2012

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