Abstract
Background
Although there is a range of different symptoms across neurodegenerative diseases, they have been noted to have common pathogenic features. An archetypal feature shared between these diseases is protein misfolding; however, the mechanism behind the proteins abnormalities is still under investigation. There is an emerging hypothesis in the literature that the mechanisms that lead to protein misfolding may be shared across neurodegenerative processes, suggesting a common underlying pathology.
Main body
This review discusses the literature to date of the shared features of protein misfolding, failures in proteostasis, and potential propagation pathways across the main neurodegenerative disorders.
Conclusion
The current data suggests, despite overarching processes being shared, that the molecular events implicated in protein pathology are distinct across common neurodegenerative disorders.
Although there is a range of different symptoms across neurodegenerative diseases, they have been noted to have common pathogenic features. An archetypal feature shared between these diseases is protein misfolding; however, the mechanism behind the proteins abnormalities is still under investigation. There is an emerging hypothesis in the literature that the mechanisms that lead to protein misfolding may be shared across neurodegenerative processes, suggesting a common underlying pathology.
Main body
This review discusses the literature to date of the shared features of protein misfolding, failures in proteostasis, and potential propagation pathways across the main neurodegenerative disorders.
Conclusion
The current data suggests, despite overarching processes being shared, that the molecular events implicated in protein pathology are distinct across common neurodegenerative disorders.
| Original language | English |
|---|---|
| Article number | 35 (2019) |
| Number of pages | 7 |
| Journal | Neurological Research and Practice |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 16 Sept 2019 |
Research Groups and Themes
- Physical and Mental Health
Keywords
- Neurodegeneration
- Protein Aggregates
- Protein folding
Access to Document
- Full-text PDF (final published version)
This is the final published version of the article (version of record). It first appeared online via BMC at https://neurolrespract.biomedcentral.com/articles/10.1186/s42466-019-0039-8 . Please refer to any applicable terms of use of the publisher.