Monoamine oxidase-A selective inhibition in human hypothalamus and liver in-vitro by amiflamine and its metabolites

K F Tipton, A M O'Carroll, J M McCrodden, C J Fowler

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)

Abstract

Amiflamine (FLA 336(+] and its two metabolites, FLA 788(+) and FLA 668(+) were found to be competitive inhibitors of the activity of monoamine oxidase-A in homogenates of human hypothalamus and liver obtained at autopsy. Ki values, determined at pH 7.2, were 1.3, 0.3 and 22 microM (liver) and 0.8, 0.2 and 14 microM (hypothalamus) for amiflamine, FLA 788(+) and FLA 668(+), respectively. Monoamine oxidase-B activity was only weakly inhibited by the compounds.

Original languageEnglish
Pages (from-to)352-4
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume37
Issue number5
Publication statusPublished - May 1985

Keywords

  • Animals
  • Humans
  • Hypothalamus
  • In Vitro Techniques
  • Kinetics
  • Liver
  • Monoamine Oxidase Inhibitors
  • Phenethylamines
  • Rats

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