Mortality according to CD4 count at start of combination antiretroviral therapy among HIV-infected patients followed for up to 15 years after start of treatment: collaborative cohort study

Margaret T May*, Jorg-Janne Vehreschild, Adam Trickey, Niels Obel, Peter Reiss, Fabrice Bonnet, Murielle Mary-Krause, Hasina Samji, Matthias Cavassini, Michael John Gill, Leah Shepherd, Heidi Crane, Antonella d'Arminio Monforte, Greer A Burkholder, Margaret Johnson, Paz Sobrino-Vegas, Pere Domingo, Robert Zangerle, Amy C Justice, Timothy SterlingJose M Miro, Jonathan Sterne, The Antiretroviral Therapy Cohort Collaboration (ART-CC)

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)
256 Downloads (Pure)

Abstract

Background. CD4 count at start of combination antiretroviral therapy (ART) is strongly associated with short-term survival, but its association with longer-term survival is less well characterised.

Methods. We estimated mortality rates (MR) by time since start of ART (<0.5, 0.5-0.9, 1-2.9, 3-3.9, 5-9.9 and ≥10 years) among patients from 18 European and North American cohorts who started ART during 1996-2001. Piecewise exponential models stratified by cohort were used to estimate crude and adjusted (for sex, age, transmission risk, period of starting ART [1996-7, 1998-9, 2000-1], AIDS and HIV-1 RNA at baseline) mortality rate ratios (MRR) by CD4 count at start of ART (0-49, 50-99, 100-199, 200-349, 350-499, ≥500 cells/μL) overall and separately according to time since start of ART.

Results. 6,344 of 37,496 patients died during 359,219 years of follow up. The MR per 1000 person-years was 32.8 (95% CI 30.2-35.5) during the first 6 months, declining to 16.0 (15.4, 16.8) during 5-9.9 years and 14.2 (13.3-15.1) after 10 years duration of ART. During the first year of ART there was a strong inverse association of CD4 count at start of ART with mortality. This diminished over the next 4 years. The adjusted MRR per CD4 group were 0.97 (0.94-1.00), p=0.054 and 1.02 (0.98-1.07), p=0.32 among patients followed for 5-9.9 and >10 years respectively.

Conclusions. After surviving five years of ART, the mortality of patients who started ART with low baseline CD4 count converged with mortality of patients with intermediate and high baseline CD4 counts.

Original languageEnglish
Pages (from-to)1571-1577
Number of pages7
JournalClinical Infectious Diseases
Volume62
Issue number12
Early online date29 Mar 2016
DOIs
Publication statusPublished - 15 Jun 2016

Keywords

  • HIV
  • CD4 count
  • antiretroviral therapy
  • mortality
  • cohort collaboration

Fingerprint Dive into the research topics of 'Mortality according to CD4 count at start of combination antiretroviral therapy among HIV-infected patients followed for up to 15 years after start of treatment: collaborative cohort study'. Together they form a unique fingerprint.

  • Projects

    Cite this

    May, M. T., Vehreschild, J-J., Trickey, A., Obel, N., Reiss, P., Bonnet, F., Mary-Krause, M., Samji, H., Cavassini, M., Gill, M. J., Shepherd, L., Crane, H., d'Arminio Monforte, A., Burkholder, G. A., Johnson, M., Sobrino-Vegas, P., Domingo, P., Zangerle, R., Justice, A. C., ... The Antiretroviral Therapy Cohort Collaboration (ART-CC) (2016). Mortality according to CD4 count at start of combination antiretroviral therapy among HIV-infected patients followed for up to 15 years after start of treatment: collaborative cohort study. Clinical Infectious Diseases, 62(12), 1571-1577. https://doi.org/10.1093/cid/ciw183