Mortality after total hip replacement surgery: A systematic review

J. R. Berstock*, A. D. Beswick, E. Lenguerrand, M. R. Whitehouse, A. W. Blom

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

79 Citations (Scopus)


Total hip replacement causes a short-term increase in the risk of mortality. It is important to quantify this and to identify modifiable risk factors so that the risk of post-operative mortality can be minimised. We performed a systematic review and critical evaluation of the current literature on the topic. We identified 32 studies published over the last 10 years which provide either 30-day or 90-day mortality data. We estimate the pooled incidence of mortality during the first 30 and 90 days following hip replacement to be 0.30% (95% CI 0.22 to 0.38) and 0.65% (95% CI 0.50 to 0.81), respectively. We found strong evidence of a temporal trend towards reducing mortality rates despite increasingly co-morbid patients. The risk factors for early mortality most commonly identified are increasing age, male gender and co-morbid conditions, particularly cardiovascular disease. Cardiovascular complications appear to have overtaken fatal pulmonary emboli as the leading cause of death after hip replacement.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalBone and Joint Research
Issue number6
Publication statusPublished - 1 Jun 2014

Structured keywords

  • Centre for Surgical Research


  • Hip arthroplasty
  • Meta-analysis
  • Mortality
  • Systematic review


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