Motor–cargo adaptors at the organelle–cytoskeleton interface

Research output: Contribution to journalReview article (Academic Journal)peer-review

12 Citations (Scopus)
71 Downloads (Pure)

Abstract

Cytoskeletal motors of the dynein, kinesin and myosin superfamilies maintain and adapt subcellular organelle organization to meet functional demands and support the vesicular transport of material between organelles. These motors require the capacity to specifically recognize the vesicle/organelle to be transported and are capable of selective recognition of multiple cargo. Recent studies have begun to uncover the molecular basis for motor recruitment and have highlighted the role of organelle-associated ‘cargo-adaptor’ proteins in cellular transport. These adaptors possess sequences and/or structural features that enable both motor recruitment and activation from regulated, inactive, states to enable motility on the cytoskeleton. Motor–cargo adaptor interactions define a key organelle–cytoskeleton interface, acting as crucial regulatory hubs to enable the cell to finely control membrane trafficking and organelle dynamics. Understanding the molecular basis of these interactions may offer new opportunities to control and manipulate cytoskeletal and organelle dynamics for the development of new research tools and potentially therapeutics.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume59
Early online date2 Apr 2019
DOIs
Publication statusPublished - 1 Aug 2019

Fingerprint Dive into the research topics of 'Motor–cargo adaptors at the organelle–cytoskeleton interface'. Together they form a unique fingerprint.

Cite this