Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Lavinia Paternoster; Marie Standl; Johannes Waage; Hansjörg Baurecht; Melanie Hotze; David P Strachan; John A Curtin; Klaus Bønnelykke; Chao Tian; Atsushi Takahashi; Jorge Esparza-Gordillo; Alexessander Couto Alves; Jacob P Thyssen; Herman T den Dekker; Manuel A Ferreira; Elisabeth Altmaier; Patrick M A Sleiman; Feng Li Xiao; Juan R Gonzalez; Ingo Marenholz; Birgit Kalb; Maria Pino-Yanes; Cheng-Jian Xu; Lisbeth Carstensen; Maria M Groen-Blokhuis; Cristina Venturini; Craig E Pennell; Sheila J Barton; Albert M Levin; Ivan Curjuric; Mariona Bustamante; Eskil Kreiner-Møller; Gabrielle A Lockett; Jonas Bacelis; Supinda Bunyavanich; Rachel A Myers; Anja Matanovic; Ashish Kumar; Joyce Y Tung; Tomomitsu Hirota; Michiaki Kubo; Wendy L McArdle; A John Henderson; John P Kemp; Jie Zheng; George Davey Smith; Caroline L Relton; Liesbeth Duijts; Young-Ae Lee; David M Evans; Australian Asthma Genetics Consortium (AAGC)

doi:10.1038/ng.3424

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Lavinia Paternoster, Marie Standl, Johannes Waage, Hansjörg Baurecht, Melanie Hotze, David P Strachan, John A Curtin, Klaus Bønnelykke, Chao Tian, Atsushi Takahashi, Jorge Esparza-Gordillo, Alexessander Couto Alves, Jacob P Thyssen, Herman T den Dekker, Manuel A Ferreira, Elisabeth Altmaier, Patrick M A Sleiman, Feng Li Xiao, Juan R Gonzalez, Ingo MarenholzBirgit Kalb, Maria Pino-Yanes, Cheng-Jian Xu, Lisbeth Carstensen, Maria M Groen-Blokhuis, Cristina Venturini, Craig E Pennell, Sheila J Barton, Albert M Levin, Ivan Curjuric, Mariona Bustamante, Eskil Kreiner-Møller, Gabrielle A Lockett, Jonas Bacelis, Supinda Bunyavanich, Rachel A Myers, Anja Matanovic, Ashish Kumar, Joyce Y Tung, Tomomitsu Hirota, Michiaki Kubo, Wendy L McArdle, A John Henderson, John P Kemp, Jie Zheng, George Davey Smith, Caroline L Relton, Liesbeth Duijts, Young-Ae Lee, David M Evans, Australian Asthma Genetics Consortium (AAGC)

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

296 Citations (Scopus)

311 Downloads (Pure)

Abstract

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

Original language	English
Pages (from-to)	1449-1456
Number of pages	8
Journal	Nature Genetics
Volume	47
Issue number	12
Early online date	19 Oct 2015
DOIs	https://doi.org/10.1038/ng.3424
Publication status	Published - 1 Dec 2015

Keywords

Atopic dermatitis
Genome-wide association studies

Access to Document

10.1038/ng.3424

NG_LE40675R1_Paternoster_200815Accepted author manuscript, 525 KB

3 Finished

MRC UoB UNITE Unit - Programme 1
Davey Smith, G.
1/06/13 → 31/03/18
Project: Research
MRC UoB UNITE Unit - Programme 2
Relton, C. L. & Relton, C. L.
1/06/13 → 31/03/18
Project: Research
MRC Population Health Scientist Fellowship
Paternoster, L.
1/10/12 → 1/10/16
Project: Research

EAGLE eczema consortium GWAS summary statistics
Paternoster, L. (Creator) & consortium, E. E. (Contributor), University of Bristol, 22 Feb 2016
DOI: 10.5523/bris.28uchsdpmub118uex26ylacqm, http://data.bris.ac.uk/data/dataset/28uchsdpmub118uex26ylacqm
Dataset

HPC (High Performance Computing) Facility
Susan L Pywell (Manager), Simon A Burbidge (Other), Polly E Eccleston (Other) & Simon H Atack (Other)
Facility/equipment: Facility

Dr Lavinia Paternoster
- L.Paternoster@bristol.ac.uk
- Bristol Medical School (PHS) - Senior Lecturer in Genetic Epidemiology
- Bristol Population Health Science Institute
- MRC Integrative Epidemiology Unit
Person: Academic , Member

Cite this

Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., Curtin, J. A., Bønnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A. C., Thyssen, J. P., den Dekker, H. T., Ferreira, M. A., Altmaier, E., Sleiman, P. M. A., Xiao, F. L., Gonzalez, J. R., ... Australian Asthma Genetics Consortium (AAGC) (2015). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics, 47(12), 1449-1456. https://doi.org/10.1038/ng.3424

Paternoster, Lavinia ; Standl, Marie ; Waage, Johannes ; Baurecht, Hansjörg ; Hotze, Melanie ; Strachan, David P ; Curtin, John A ; Bønnelykke, Klaus ; Tian, Chao ; Takahashi, Atsushi ; Esparza-Gordillo, Jorge ; Alves, Alexessander Couto ; Thyssen, Jacob P ; den Dekker, Herman T ; Ferreira, Manuel A ; Altmaier, Elisabeth ; Sleiman, Patrick M A ; Xiao, Feng Li ; Gonzalez, Juan R ; Marenholz, Ingo ; Kalb, Birgit ; Pino-Yanes, Maria ; Xu, Cheng-Jian ; Carstensen, Lisbeth ; Groen-Blokhuis, Maria M ; Venturini, Cristina ; Pennell, Craig E ; Barton, Sheila J ; Levin, Albert M ; Curjuric, Ivan ; Bustamante, Mariona ; Kreiner-Møller, Eskil ; Lockett, Gabrielle A ; Bacelis, Jonas ; Bunyavanich, Supinda ; Myers, Rachel A ; Matanovic, Anja ; Kumar, Ashish ; Tung, Joyce Y ; Hirota, Tomomitsu ; Kubo, Michiaki ; McArdle, Wendy L ; Henderson, A John ; Kemp, John P ; Zheng, Jie ; Smith, George Davey ; Relton, Caroline L ; Duijts, Liesbeth ; Lee, Young-Ae ; Evans, David M ; Australian Asthma Genetics Consortium (AAGC). / Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. In: Nature Genetics. 2015 ; Vol. 47, No. 12. pp. 1449-1456.

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abstract = "Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.",

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Paternoster, L, Standl, M, Waage, J, Baurecht, H, Hotze, M, Strachan, DP, Curtin, JA, Bønnelykke, K, Tian, C, Takahashi, A, Esparza-Gordillo, J, Alves, AC, Thyssen, JP, den Dekker, HT, Ferreira, MA, Altmaier, E, Sleiman, PMA, Xiao, FL, Gonzalez, JR, Marenholz, I, Kalb, B, Pino-Yanes, M, Xu, C-J, Carstensen, L, Groen-Blokhuis, MM, Venturini, C, Pennell, CE, Barton, SJ, Levin, AM, Curjuric, I, Bustamante, M, Kreiner-Møller, E, Lockett, GA, Bacelis, J, Bunyavanich, S, Myers, RA, Matanovic, A, Kumar, A, Tung, JY, Hirota, T, Kubo, M, McArdle, WL, Henderson, AJ, Kemp, JP, Zheng, J , Smith, GD , Relton, CL, Duijts, L, Lee, Y-A, Evans, DM & Australian Asthma Genetics Consortium (AAGC) 2015, 'Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis', Nature Genetics, vol. 47, no. 12, pp. 1449-1456. https://doi.org/10.1038/ng.3424

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. / Paternoster, Lavinia; Standl, Marie; Waage, Johannes; Baurecht, Hansjörg; Hotze, Melanie; Strachan, David P; Curtin, John A; Bønnelykke, Klaus; Tian, Chao; Takahashi, Atsushi; Esparza-Gordillo, Jorge; Alves, Alexessander Couto; Thyssen, Jacob P; den Dekker, Herman T; Ferreira, Manuel A; Altmaier, Elisabeth; Sleiman, Patrick M A; Xiao, Feng Li; Gonzalez, Juan R; Marenholz, Ingo; Kalb, Birgit; Pino-Yanes, Maria; Xu, Cheng-Jian; Carstensen, Lisbeth; Groen-Blokhuis, Maria M; Venturini, Cristina; Pennell, Craig E; Barton, Sheila J; Levin, Albert M; Curjuric, Ivan; Bustamante, Mariona; Kreiner-Møller, Eskil; Lockett, Gabrielle A; Bacelis, Jonas; Bunyavanich, Supinda; Myers, Rachel A; Matanovic, Anja; Kumar, Ashish; Tung, Joyce Y; Hirota, Tomomitsu; Kubo, Michiaki; McArdle, Wendy L; Henderson, A John; Kemp, John P; Zheng, Jie ; Smith, George Davey ; Relton, Caroline L; Duijts, Liesbeth; Lee, Young-Ae; Evans, David M; Australian Asthma Genetics Consortium (AAGC).

In: Nature Genetics, Vol. 47, No. 12, 01.12.2015, p. 1449-1456.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

TY - JOUR

T1 - Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

AU - Paternoster, Lavinia

AU - Standl, Marie

AU - Waage, Johannes

AU - Baurecht, Hansjörg

AU - Hotze, Melanie

AU - Strachan, David P

AU - Curtin, John A

AU - Bønnelykke, Klaus

AU - Tian, Chao

AU - Takahashi, Atsushi

AU - Esparza-Gordillo, Jorge

AU - Alves, Alexessander Couto

AU - Thyssen, Jacob P

AU - den Dekker, Herman T

AU - Ferreira, Manuel A

AU - Altmaier, Elisabeth

AU - Sleiman, Patrick M A

AU - Xiao, Feng Li

AU - Gonzalez, Juan R

AU - Marenholz, Ingo

AU - Kalb, Birgit

AU - Pino-Yanes, Maria

AU - Xu, Cheng-Jian

AU - Carstensen, Lisbeth

AU - Groen-Blokhuis, Maria M

AU - Venturini, Cristina

AU - Pennell, Craig E

AU - Barton, Sheila J

AU - Levin, Albert M

AU - Curjuric, Ivan

AU - Bustamante, Mariona

AU - Kreiner-Møller, Eskil

AU - Lockett, Gabrielle A

AU - Bacelis, Jonas

AU - Bunyavanich, Supinda

AU - Myers, Rachel A

AU - Matanovic, Anja

AU - Kumar, Ashish

AU - Tung, Joyce Y

AU - Hirota, Tomomitsu

AU - Kubo, Michiaki

AU - McArdle, Wendy L

AU - Henderson, A John

AU - Kemp, John P

AU - Zheng, Jie

AU - Smith, George Davey

AU - Relton, Caroline L

AU - Duijts, Liesbeth

AU - Lee, Young-Ae

AU - Evans, David M

AU - Australian Asthma Genetics Consortium (AAGC)

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

AB - Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

KW - Atopic dermatitis

KW - Genome-wide association studies

U2 - 10.1038/ng.3424

DO - 10.1038/ng.3424

M3 - Letter (Academic Journal)

C2 - 26482879

VL - 47

SP - 1449

EP - 1456

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 12

ER -

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Abstract

Keywords

Access to Document

Fingerprint

Projects

MRC UoB UNITE Unit - Programme 1

MRC UoB UNITE Unit - Programme 2

MRC Population Health Scientist Fellowship

Datasets

EAGLE eczema consortium GWAS summary statistics

Equipment

HPC (High Performance Computing) Facility

Profiles

Dr Lavinia Paternoster

Cite this