Multi-layered genome defences in bacteria

Aleksei Agapov; Kate S Baker; Paritosh Bedekar; Rama P Bhatia; Tim R Blower; Michael A Brockhurst; Cooper Brown; Charlotte E Chong; Joanne L Fothergill; Shirley Graham; James Pj Hall; Alice Maestri; Stuart McQuarrie; Anna Olina; Stefano Pagliara; Mario Recker; Anna Richmond; Steven J Shaw; Mark D Szczelkun; Tiffany B Taylor; Stineke van Houte; Sam C Went; Edze R Westra; Malcolm F White; Rosanna Wright

doi:10.1016/j.mib.2024.102436

Multi-layered genome defences in bacteria

Aleksei Agapov, Kate S Baker, Paritosh Bedekar, Rama P Bhatia, Tim R Blower, Michael A Brockhurst, Cooper Brown, Charlotte E Chong, Joanne L Fothergill, Shirley Graham, James Pj Hall, Alice Maestri, Stuart McQuarrie, Anna Olina, Stefano Pagliara, Mario Recker, Anna Richmond, Steven J Shaw, Mark D Szczelkun, Tiffany B TaylorStineke van Houte, Sam C Went, Edze R Westra^*, Malcolm F White, Rosanna Wright

^*Corresponding author for this work

School of Biochemistry

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

2 Citations (Scopus)

Abstract

Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.

Original language	English
Article number	102436
Number of pages	10
Journal	Current Opinion in Microbiology
Volume	78
Early online date	17 Feb 2024
DOIs	https://doi.org/10.1016/j.mib.2024.102436
Publication status	Published - 1 Apr 2024

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Publisher Copyright:
© 2024 The Authors

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Agapov, A., Baker, K. S., Bedekar, P., Bhatia, R. P., Blower, T. R., Brockhurst, M. A., Brown, C., Chong, C. E., Fothergill, J. L., Graham, S., Hall, J. P., Maestri, A., McQuarrie, S., Olina, A., Pagliara, S., Recker, M., Richmond, A., Shaw, S. J., Szczelkun, M. D., ... Wright, R. (2024). Multi-layered genome defences in bacteria. Current Opinion in Microbiology, 78, Article 102436. https://doi.org/10.1016/j.mib.2024.102436

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title = "Multi-layered genome defences in bacteria",

abstract = "Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.",

author = "Aleksei Agapov and Baker, {Kate S} and Paritosh Bedekar and Bhatia, {Rama P} and Blower, {Tim R} and Brockhurst, {Michael A} and Cooper Brown and Chong, {Charlotte E} and Fothergill, {Joanne L} and Shirley Graham and Hall, {James Pj} and Alice Maestri and Stuart McQuarrie and Anna Olina and Stefano Pagliara and Mario Recker and Anna Richmond and Shaw, {Steven J} and Szczelkun, {Mark D} and Taylor, {Tiffany B} and {van Houte}, Stineke and Went, {Sam C} and Westra, {Edze R} and White, {Malcolm F} and Rosanna Wright",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = apr,

day = "1",

doi = "10.1016/j.mib.2024.102436",

language = "English",

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Agapov, A, Baker, KS, Bedekar, P, Bhatia, RP, Blower, TR, Brockhurst, MA, Brown, C, Chong, CE, Fothergill, JL, Graham, S, Hall, JP, Maestri, A, McQuarrie, S, Olina, A, Pagliara, S, Recker, M, Richmond, A, Shaw, SJ , Szczelkun, MD, Taylor, TB, van Houte, S, Went, SC, Westra, ER, White, MF & Wright, R 2024, 'Multi-layered genome defences in bacteria', Current Opinion in Microbiology, vol. 78, 102436. https://doi.org/10.1016/j.mib.2024.102436

TY - JOUR

T1 - Multi-layered genome defences in bacteria

AU - Agapov, Aleksei

AU - Baker, Kate S

AU - Bedekar, Paritosh

AU - Bhatia, Rama P

AU - Blower, Tim R

AU - Brockhurst, Michael A

AU - Brown, Cooper

AU - Chong, Charlotte E

AU - Fothergill, Joanne L

AU - Graham, Shirley

AU - Hall, James Pj

AU - Maestri, Alice

AU - McQuarrie, Stuart

AU - Olina, Anna

AU - Pagliara, Stefano

AU - Recker, Mario

AU - Richmond, Anna

AU - Shaw, Steven J

AU - Szczelkun, Mark D

AU - Taylor, Tiffany B

AU - van Houte, Stineke

AU - Went, Sam C

AU - Westra, Edze R

AU - White, Malcolm F

AU - Wright, Rosanna

PY - 2024/4/1

Y1 - 2024/4/1

N2 - Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.

AB - Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.

U2 - 10.1016/j.mib.2024.102436

DO - 10.1016/j.mib.2024.102436

M3 - Review article (Academic Journal)

C2 - 38368839

SN - 1369-5274

VL - 78

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

M1 - 102436

ER -

Multi-layered genome defences in bacteria

Abstract

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