Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Florence  Demenais; Raquel Granell; John Henderson; Wendy McArdle; Dan Nicolae

doi:10.1038/s41588-017-0014-7

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Florence Demenais, Raquel Granell, John Henderson, Wendy McArdle, Dan Nicolae

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Abstract

We examined common variation in asthma risk by conducting the largest meta-analysis to date of asthma genome-wide association studies (23,948 cases, 118,538 controls) from multi-ancestry populations. We identified five new asthma loci, uncovered two novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma loci near enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms.

Original language	English
Pages (from-to)	42-53
Number of pages	12
Journal	Nature Genetics
Volume	50
Early online date	22 Dec 2017
DOIs	https://doi.org/10.1038/s41588-017-0014-7
Publication status	Published - 1 Jan 2018

Keywords

Asthma
Genetics

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10.1038/s41588-017-0014-7

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Nature Publishing Group at https://www.nature.com/articles/s41588-017-0014-7 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 1.58 MB
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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Nature Publishing Group at https://www.nature.com/articles/s41588-017-0014-7 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 11.3 MB

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THE NATURAL HISTORY OF ASTHMA AND WHEEZING ILLNESSES FROM BIRTH TO ADOLESCENCE: DETERMINANTS OF THE REMISSION OF ASTHMA
Henderson, A. J. W. (Principal Investigator)
1/10/06 → 1/10/10
Project: Research
EXTENSION OF RD1321 VIA IOP.
Golding, J. (Principal Investigator)
1/02/01 → 1/02/06
Project: Research

Dr Raquel Granell
- Raquel.Granellbristol.acuk
- Bristol Medical School (PHS) - Research Fellow in Primary Care
- Bristol Population Health Science Institute
Person: Academic , Member

Cite this

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title = "Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks",

abstract = "We examined common variation in asthma risk by conducting the largest meta-analysis to date of asthma genome-wide association studies (23,948 cases, 118,538 controls) from multi-ancestry populations. We identified five new asthma loci, uncovered two novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma loci near enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms.",

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AU - Demenais, Florence

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AU - McArdle, Wendy

AU - Nicolae, Dan

PY - 2018/1/1

Y1 - 2018/1/1

N2 - We examined common variation in asthma risk by conducting the largest meta-analysis to date of asthma genome-wide association studies (23,948 cases, 118,538 controls) from multi-ancestry populations. We identified five new asthma loci, uncovered two novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma loci near enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms.

AB - We examined common variation in asthma risk by conducting the largest meta-analysis to date of asthma genome-wide association studies (23,948 cases, 118,538 controls) from multi-ancestry populations. We identified five new asthma loci, uncovered two novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma loci near enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms.

KW - Asthma

KW - Genetics

U2 - 10.1038/s41588-017-0014-7

DO - 10.1038/s41588-017-0014-7

M3 - Article (Academic Journal)

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EP - 53

JO - Nature Genetics

JF - Nature Genetics

ER -

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

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Keywords

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Projects

THE NATURAL HISTORY OF ASTHMA AND WHEEZING ILLNESSES FROM BIRTH TO ADOLESCENCE: DETERMINANTS OF THE REMISSION OF ASTHMA

EXTENSION OF RD1321 VIA IOP.

Profiles

Dr Raquel Granell

Cite this