Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Florence Demenais, Raquel Granell, John Henderson, Wendy McArdle, Dan Nicolae

Research output: Contribution to journalArticle (Academic Journal)peer-review

146 Citations (Scopus)
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Abstract

We examined common variation in asthma risk by conducting the largest meta-analysis to date of asthma genome-wide association studies (23,948 cases, 118,538 controls) from multi-ancestry populations. We identified five new asthma loci, uncovered two novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma loci near enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms.
Original languageEnglish
Pages (from-to)42-53
Number of pages12
JournalNature Genetics
Volume50
Early online date22 Dec 2017
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Asthma
  • Genetics

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