Projects per year
We examined common variation in asthma risk by conducting the largest meta-analysis to date of asthma genome-wide association studies (23,948 cases, 118,538 controls) from multi-ancestry populations. We identified five new asthma loci, uncovered two novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma loci near enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms.
THE NATURAL HISTORY OF ASTHMA AND WHEEZING ILLNESSES FROM BIRTH TO ADOLESCENCE: DETERMINANTS OF THE REMISSION OF ASTHMA
Henderson, A. J. W.
1/10/06 → 1/10/10