Multicenter study of intravitreal dexamethasone implant in non-infectious Uveitis: Indications, outcomes and reinjection frequency

Javier Zarranz-Ventura, Ester Carreño, Robert L Johnston, Quresh Mohammed, Adam H Ross, Carl Barker, Alex Fonollosa, Joseba Artaraz, Laura Pelegrin, Alfredo Adan, Richard W Lee, Andrew D Dick, Ahmed Sallam

Research output: Contribution to journalArticle (Academic Journal)peer-review

78 Citations (Scopus)

Abstract

PURPOSE: To identify clinical outcomes and treatment patterns of intravitreal dexamethasone implant (Ozurdex®) in non-infectious uveitis in the clinical setting.

DESIGN: Multicenter retrospective cohort study.

METHODS: 82 eyes (63 patients) receiving 142 implant injections over 35 months were included. Treatment indication, uveitis diagnosis, visual acuity, intraocular pressure, vitreous haze score, central retinal thickness by optical coherence tomography, phakic status, number of injections, time to reinjection, systemic treatments and complications data were collected. Time to visual acuity and vitreous haze score improvement as per the Standardization of Uveitis Nomenclature guidelines were also determined.

RESULTS: The probability of visual acuity improvement (≥ 0.3 logarithm of the minimum angle of resolution units improvement) was 39% at 1 month, 49% at 3 months, 52% at 6 months and 58% at 12 months. Eyes with baseline vitritis (vitreous haze score ≥ +0.5, n = 45) had a probability of vitreous haze score improvement (2-step decrease or change from +0.5 to 0) at 2 weeks of 41%, at 1 month 63%, at 3 months 73%, at 6 months 79% and at 12 months 88%. In eyes which completed 12 months follow-up (n = 54), 40.7% underwent 2 injections (mean time to second injection of 6.6 ± 1.9 months) and 11.2% required ≥ 3 injections (mean time to third injection of 11 ± 1.5 months).

CONCLUSIONS: Dexamethasone implant use in uveitis provides favourable visual acuity and vitreous haze score outcomes but requires repeated injections, an important consideration when choosing intraocular treatment as a route to controlling uveitis.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
DOIs
Publication statusPublished - 8 Sep 2014

Bibliographical note

Copyright © 2014 Elsevier Inc. All rights reserved.

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