Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

Maria Sabater-Lleal; Jie Huang; Daniel Chasman; Silvia Naitza; Abbas Dehghan; Andrew D Johnson; Alexander Teumer; Alex P Reiner; Lasse Folkersen; Saonli Basu; Alicja R Rudnicka; Stella Trompet; Anders Mälarstig; Jens Baumert; Joshua C Bis; Xiuqing Guo; Jouke J Hottenga; So-Youn Shin; Lorna M Lopez; Jari Lahti; Toshiko Tanaka; Lisa R Yanek; Tiphaine Oudot-Mellakh; James F Wilson; Pau Navarro; Jennifer E Huffman; Tatijana Zemunik; Susan Redline; Reena Mehra; Drazen Pulanic; Igor Rudan; Alan F Wright; Ivana Kolcic; Ozren Polasek; Sarah H Wild; Harry Campbell; J David Curb; Robert Wallace; Simin Liu; Charles B Eaton; Diane M Becker; Lewis C Becker; Stefania Bandinelli; Katri Räikkönen; Elisabeth Widen; Aarno Palotie; Myriam Fornage; David Green; Myron Gross; Wendy L McArdle; VTE Consortium

doi:10.1161/CIRCULATIONAHA.113.002251

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

Maria Sabater-Lleal, Jie Huang, Daniel Chasman, Silvia Naitza, Abbas Dehghan, Andrew D Johnson, Alexander Teumer, Alex P Reiner, Lasse Folkersen, Saonli Basu, Alicja R Rudnicka, Stella Trompet, Anders Mälarstig, Jens Baumert, Joshua C Bis, Xiuqing Guo, Jouke J Hottenga, So-Youn Shin, Lorna M Lopez, Jari LahtiToshiko Tanaka, Lisa R Yanek, Tiphaine Oudot-Mellakh, James F Wilson, Pau Navarro, Jennifer E Huffman, Tatijana Zemunik, Susan Redline, Reena Mehra, Drazen Pulanic, Igor Rudan, Alan F Wright, Ivana Kolcic, Ozren Polasek, Sarah H Wild, Harry Campbell, J David Curb, Robert Wallace, Simin Liu, Charles B Eaton, Diane M Becker, Lewis C Becker, Stefania Bandinelli, Katri Räikkönen, Elisabeth Widen, Aarno Palotie, Myriam Fornage, David Green, Myron Gross, Wendy L McArdle, VTE Consortium

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

127 Citations (Scopus)

Abstract

Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (

Original language	English
Pages (from-to)	1310-24
Number of pages	15
Journal	Circulation
Volume	128
Issue number	12
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.113.002251
Publication status	Published - 17 Sept 2013

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MRC UoB UNITE Unit - Programme 1
Davey Smith, G. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research

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Sabater-Lleal, M., Huang, J., Chasman, D., Naitza, S., Dehghan, A., Johnson, A. D., Teumer, A., Reiner, A. P., Folkersen, L., Basu, S., Rudnicka, A. R., Trompet, S., Mälarstig, A., Baumert, J., Bis, J. C., Guo, X., Hottenga, J. J., Shin, S.-Y., Lopez, L. M., ... VTE Consortium (2013). Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation, 128(12), 1310-24. https://doi.org/10.1161/CIRCULATIONAHA.113.002251

@article{242ecef04cde41839aaf20069456c96e,

title = "Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease",

abstract = "Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34\% to 50\%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (",

author = "Maria Sabater-Lleal and Jie Huang and Daniel Chasman and Silvia Naitza and Abbas Dehghan and Johnson, \{Andrew D\} and Alexander Teumer and Reiner, \{Alex P\} and Lasse Folkersen and Saonli Basu and Rudnicka, \{Alicja R\} and Stella Trompet and Anders M{\"a}larstig and Jens Baumert and Bis, \{Joshua C\} and Xiuqing Guo and Hottenga, \{Jouke J\} and So-Youn Shin and Lopez, \{Lorna M\} and Jari Lahti and Toshiko Tanaka and Yanek, \{Lisa R\} and Tiphaine Oudot-Mellakh and Wilson, \{James F\} and Pau Navarro and Huffman, \{Jennifer E\} and Tatijana Zemunik and Susan Redline and Reena Mehra and Drazen Pulanic and Igor Rudan and Wright, \{Alan F\} and Ivana Kolcic and Ozren Polasek and Wild, \{Sarah H\} and Harry Campbell and Curb, \{J David\} and Robert Wallace and Simin Liu and Eaton, \{Charles B\} and Becker, \{Diane M\} and Becker, \{Lewis C\} and Stefania Bandinelli and Katri R{\"a}ikk{\"o}nen and Elisabeth Widen and Aarno Palotie and Myriam Fornage and David Green and Myron Gross and McArdle, \{Wendy L\} and \{VTE Consortium\}",

year = "2013",

month = sep,

day = "17",

doi = "10.1161/CIRCULATIONAHA.113.002251",

language = "English",

volume = "128",

pages = "1310--24",

journal = "Circulation",

issn = "1524-4539",

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}

Sabater-Lleal, M, Huang, J, Chasman, D, Naitza, S, Dehghan, A, Johnson, AD, Teumer, A, Reiner, AP, Folkersen, L, Basu, S, Rudnicka, AR, Trompet, S, Mälarstig, A, Baumert, J, Bis, JC, Guo, X, Hottenga, JJ, Shin, S-Y, Lopez, LM, Lahti, J, Tanaka, T, Yanek, LR, Oudot-Mellakh, T, Wilson, JF, Navarro, P, Huffman, JE, Zemunik, T, Redline, S, Mehra, R, Pulanic, D, Rudan, I, Wright, AF, Kolcic, I, Polasek, O, Wild, SH, Campbell, H, Curb, JD, Wallace, R, Liu, S, Eaton, CB, Becker, DM, Becker, LC, Bandinelli, S, Räikkönen, K, Widen, E, Palotie, A, Fornage, M, Green, D, Gross, M, McArdle, WL & VTE Consortium 2013, 'Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease', Circulation, vol. 128, no. 12, pp. 1310-24. https://doi.org/10.1161/CIRCULATIONAHA.113.002251

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. / Sabater-Lleal, Maria; Huang, Jie; Chasman, Daniel et al.
In: Circulation, Vol. 128, No. 12, 17.09.2013, p. 1310-24.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

AU - Sabater-Lleal, Maria

AU - Huang, Jie

AU - Chasman, Daniel

AU - Naitza, Silvia

AU - Dehghan, Abbas

AU - Johnson, Andrew D

AU - Teumer, Alexander

AU - Reiner, Alex P

AU - Folkersen, Lasse

AU - Basu, Saonli

AU - Rudnicka, Alicja R

AU - Trompet, Stella

AU - Mälarstig, Anders

AU - Baumert, Jens

AU - Bis, Joshua C

AU - Guo, Xiuqing

AU - Hottenga, Jouke J

AU - Shin, So-Youn

AU - Lopez, Lorna M

AU - Lahti, Jari

AU - Tanaka, Toshiko

AU - Yanek, Lisa R

AU - Oudot-Mellakh, Tiphaine

AU - Wilson, James F

AU - Navarro, Pau

AU - Huffman, Jennifer E

AU - Zemunik, Tatijana

AU - Redline, Susan

AU - Mehra, Reena

AU - Pulanic, Drazen

AU - Rudan, Igor

AU - Wright, Alan F

AU - Kolcic, Ivana

AU - Polasek, Ozren

AU - Wild, Sarah H

AU - Campbell, Harry

AU - Curb, J David

AU - Wallace, Robert

AU - Liu, Simin

AU - Eaton, Charles B

AU - Becker, Diane M

AU - Becker, Lewis C

AU - Bandinelli, Stefania

AU - Räikkönen, Katri

AU - Widen, Elisabeth

AU - Palotie, Aarno

AU - Fornage, Myriam

AU - Green, David

AU - Gross, Myron

AU - McArdle, Wendy L

AU - VTE Consortium

PY - 2013/9/17

Y1 - 2013/9/17

N2 - Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (

AB - Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (

U2 - 10.1161/CIRCULATIONAHA.113.002251

DO - 10.1161/CIRCULATIONAHA.113.002251

M3 - Article (Academic Journal)

C2 - 23969696

SN - 1524-4539

VL - 128

SP - 1310

EP - 1324

JO - Circulation

JF - Circulation

IS - 12

ER -

Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD et al. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 2013 Sept 17;128(12):1310-24. doi: 10.1161/CIRCULATIONAHA.113.002251

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

Abstract

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