Multiple Deeply Divergent Denisovan Ancestries in Papuans

Guy Jacobs, Georgi Hudjashov*, Lauri Saag, Pradiptajati Kusuma, Chelzie C Darusallam, Daniel Lawson, Mayukh Mondal, Luca Pagani, Francois-Xavier Ricaut, Mark Stoneking, Mait Metspalu, Herawati Sudoyu, J Stephen Lansing, Murray P. Cox

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

53 Citations (Scopus)
55 Downloads (Pure)

Abstract

Genome sequences are known for two archaic hominins – Neanderthals and Denisovans – which interbred with anatomically modern humans as they dispersed out of Africa. We identified high-confidence archaic haplotypes in 161 new genomes spanning 14 island groups in Island Southeast Asia and New Guinea, and found large stretches of DNA that are inconsistent with a single introgressing Denisovan origin. Instead, modern Papuans carry hundreds of gene variants from two deeply divergent Denisovan lineages that separated over 350 thousand years ago. Spatial and temporal structure among these lineages suggest that introgression from one of these Denisovan groups predominantly took place east of the Wallace line and continued until near the end of the Pleistocene. A third Denisovan lineage occurs in modern East Asians. This regional mosaic suggests considerable complexity in archaic contact, with modern humans interbreeding with multiple Denisovan groups that were geographically isolated from each other over deep evolutionary time.
Original languageEnglish
Pages (from-to)1010-1021.e32
Number of pages45
JournalCell
Volume177
Issue number4
Early online date11 Apr 2019
DOIs
Publication statusPublished - 2 May 2019

Keywords

  • archaic ancestry
  • Denisovan
  • Neanderthal
  • Island Southeast Asia
  • Indonesia
  • New Guinea

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