Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis

M Islam, T H Jafar, A R Wood, N M G De Silva, M Caulfield, N Chaturvedi, T M Frayling

Research output: Contribution to journalArticle (Academic Journal)peer-review

6 Citations (Scopus)

Abstract

Multiple genetic variants are associated with type 2 diabetes-related traits in Europeans, but their role in South Asian populations needs further study. We hypothesised that genetic variants associated with diabetes-related traits in Europeans would explain a similar proportion of phenotypic variance in a Pakistani population and could be used in Mendelian randomisation analyses.
Original languageEnglish
Pages (from-to)2193-204
Number of pages12
JournalDiabetologia
Volume55
Issue number8
DOIs
Publication statusPublished - Aug 2012

Keywords

  • Analysis of Variance
  • Blood Glucose
  • Blood Pressure
  • Body Mass Index
  • Diabetes Mellitus, Type 2
  • European Continental Ancestry Group
  • Fasting
  • Female
  • Genetic Predisposition to Disease
  • Great Britain
  • Humans
  • Male
  • Mendelian Randomization Analysis
  • Middle Aged
  • Pakistan
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Triglycerides

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