Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis

M Islam; T H Jafar; A R Wood; N M G De Silva; M Caulfield; N Chaturvedi; T M Frayling

doi:10.1007/s00125-012-2560-y

Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis

M Islam, T H Jafar, A R Wood, N M G De Silva, M Caulfield, N Chaturvedi, T M Frayling

Research output: Contribution to journal › Article (Academic Journal) › peer-review

12 Citations (Scopus)

Abstract

Multiple genetic variants are associated with type 2 diabetes-related traits in Europeans, but their role in South Asian populations needs further study. We hypothesised that genetic variants associated with diabetes-related traits in Europeans would explain a similar proportion of phenotypic variance in a Pakistani population and could be used in Mendelian randomisation analyses.

Original language	English
Pages (from-to)	2193-204
Number of pages	12
Journal	Diabetologia
Volume	55
Issue number	8
DOIs	https://doi.org/10.1007/s00125-012-2560-y
Publication status	Published - Aug 2012

Keywords

Analysis of Variance
Blood Glucose
Blood Pressure
Body Mass Index
Diabetes Mellitus, Type 2
European Continental Ancestry Group
Fasting
Female
Genetic Predisposition to Disease
Great Britain
Humans
Male
Mendelian Randomization Analysis
Middle Aged
Pakistan
Phenotype
Polymorphism, Single Nucleotide
Risk Factors
Triglycerides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00125-012-2560-y

Handle.net

Persistent link

Cite this

@article{3a1b5d73c3974621813f05a61d5c7ab5,

title = "Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis",

abstract = "Multiple genetic variants are associated with type 2 diabetes-related traits in Europeans, but their role in South Asian populations needs further study. We hypothesised that genetic variants associated with diabetes-related traits in Europeans would explain a similar proportion of phenotypic variance in a Pakistani population and could be used in Mendelian randomisation analyses.",

keywords = "Analysis of Variance, Blood Glucose, Blood Pressure, Body Mass Index, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Fasting, Female, Genetic Predisposition to Disease, Great Britain, Humans, Male, Mendelian Randomization Analysis, Middle Aged, Pakistan, Phenotype, Polymorphism, Single Nucleotide, Risk Factors, Triglycerides",

author = "M Islam and Jafar, \{T H\} and Wood, \{A R\} and \{De Silva\}, \{N M G\} and M Caulfield and N Chaturvedi and Frayling, \{T M\}",

year = "2012",

month = aug,

doi = "10.1007/s00125-012-2560-y",

language = "English",

volume = "55",

pages = "2193--204",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "8",

}

TY - JOUR

T1 - Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis

AU - Islam, M

AU - Jafar, T H

AU - Wood, A R

AU - De Silva, N M G

AU - Caulfield, M

AU - Chaturvedi, N

AU - Frayling, T M

PY - 2012/8

Y1 - 2012/8

N2 - Multiple genetic variants are associated with type 2 diabetes-related traits in Europeans, but their role in South Asian populations needs further study. We hypothesised that genetic variants associated with diabetes-related traits in Europeans would explain a similar proportion of phenotypic variance in a Pakistani population and could be used in Mendelian randomisation analyses.

AB - Multiple genetic variants are associated with type 2 diabetes-related traits in Europeans, but their role in South Asian populations needs further study. We hypothesised that genetic variants associated with diabetes-related traits in Europeans would explain a similar proportion of phenotypic variance in a Pakistani population and could be used in Mendelian randomisation analyses.

KW - Analysis of Variance

KW - Blood Glucose

KW - Blood Pressure

KW - Body Mass Index

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Fasting

KW - Female

KW - Genetic Predisposition to Disease

KW - Great Britain

KW - Humans

KW - Male

KW - Mendelian Randomization Analysis

KW - Middle Aged

KW - Pakistan

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

KW - Triglycerides

U2 - 10.1007/s00125-012-2560-y

DO - 10.1007/s00125-012-2560-y

M3 - Article (Academic Journal)

C2 - 22538361

SN - 0012-186X

VL - 55

SP - 2193

EP - 2204

JO - Diabetologia

JF - Diabetologia

IS - 8

ER -

Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis

Abstract

Keywords

UN SDGs

Access to Document

Handle.net

Fingerprint

Cite this