Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

Gabor G. Kovacs; Sharon X. Xie; Edward B. Lee; John L. Robinson; Carrie Caswell; David J. Irwin; Jon B. Toledo; Victoria E. Johnson; Douglas H. Smith; Irina Alafuzoff; Johannes Attems; Janos Bencze; Kevin F. Bieniek; Eileen H. Bigio; Istvan Bodi; Herbert Budka; Dennis W. Dickson; Brittany N. Dugger; Charles Duyckaerts; Isidro Ferrer; Shelley L. Forrest; Ellen Gelpi; Stephen M. Gentleman; Giorgio Giaccone; Lea T. Grinberg; Glenda M. Halliday; Kimmo J. Hatanpaa; Patrick R. Hof; Monika Hofer; Tibor Hortobágyi; James W. Ironside; Andrew King; Julia Kofler; Enikö Kövari; Jillian J. Kril; Seth Love; Ian R. Mackenzie; Qinwen Mao; Radoslav Matej; Catriona McLean; David G. Munoz; Melissa E. Murray; Janna Neltner; Peter T. Nelson; Diane Ritchie; Roberta D. Rodriguez; Zdenek Rohan; Annemieke Rozemuller; Kenji Sakai; Christian Schultz; Danielle Seilhean; Vanessa Smith; Pawel Tacik; Hitoshi Takahashi; Masaki Takao; Dietmar Rudolf Thal; Serge Weis; Stephen B. Wharton; Charles L. White; John M. Woulfe; Masahito Yamada; John Q. Trojanowski

doi:10.1093/jnen/nlx041

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

Gabor G. Kovacs^*, Sharon X. Xie, Edward B. Lee, John L. Robinson, Carrie Caswell, David J. Irwin, Jon B. Toledo, Victoria E. Johnson, Douglas H. Smith, Irina Alafuzoff, Johannes Attems, Janos Bencze, Kevin F. Bieniek, Eileen H. Bigio, Istvan Bodi, Herbert Budka, Dennis W. Dickson, Brittany N. Dugger, Charles Duyckaerts, Isidro FerrerShelley L. Forrest, Ellen Gelpi, Stephen M. Gentleman, Giorgio Giaccone, Lea T. Grinberg, Glenda M. Halliday, Kimmo J. Hatanpaa, Patrick R. Hof, Monika Hofer, Tibor Hortobágyi, James W. Ironside, Andrew King, Julia Kofler, Enikö Kövari, Jillian J. Kril, Seth Love, Ian R. Mackenzie, Qinwen Mao, Radoslav Matej, Catriona McLean, David G. Munoz, Melissa E. Murray, Janna Neltner, Peter T. Nelson, Diane Ritchie, Roberta D. Rodriguez, Zdenek Rohan, Annemieke Rozemuller, Kenji Sakai, Christian Schultz, Danielle Seilhean, Vanessa Smith, Pawel Tacik, Hitoshi Takahashi, Masaki Takao, Dietmar Rudolf Thal, Serge Weis, Stephen B. Wharton, Charles L. White, John M. Woulfe, Masahito Yamada, John Q. Trojanowski

^*Corresponding author for this work

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Abstract

Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was >60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (>90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.

Original language	English
Pages (from-to)	605-619
Number of pages	15
Journal	Journal of Neuropathology and Experimental Neurology
Volume	76
Issue number	7
Early online date	7 Jun 2017
DOIs	https://doi.org/10.1093/jnen/nlx041
Publication status	Published - 15 Jul 2017

Research Groups and Themes

Cerebrovascular and Dementia Research Group

Keywords

Aging
ARTAG
Digital pathology
Interrater agreement
Neuropathology
Tau
Tau-astrogliopathy

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10.1093/jnen/nlx041

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Kovacs, G. G., Xie, S. X., Lee, E. B., Robinson, J. L., Caswell, C., Irwin, D. J., Toledo, J. B., Johnson, V. E., Smith, D. H., Alafuzoff, I., Attems, J., Bencze, J., Bieniek, K. F., Bigio, E. H., Bodi, I., Budka, H., Dickson, D. W., Dugger, B. N., Duyckaerts, C., ... Trojanowski, J. Q. (2017). Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of Neuropathology and Experimental Neurology, 76(7), 605-619. https://doi.org/10.1093/jnen/nlx041

@article{6d141c924d0341148ec3a7a78cd4cdb3,

title = "Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)",

abstract = "Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was >60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (>90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.",

keywords = "Aging, ARTAG, Digital pathology, Interrater agreement, Neuropathology, Tau, Tau-astrogliopathy",

author = "Kovacs, {Gabor G.} and Xie, {Sharon X.} and Lee, {Edward B.} and Robinson, {John L.} and Carrie Caswell and Irwin, {David J.} and Toledo, {Jon B.} and Johnson, {Victoria E.} and Smith, {Douglas H.} and Irina Alafuzoff and Johannes Attems and Janos Bencze and Bieniek, {Kevin F.} and Bigio, {Eileen H.} and Istvan Bodi and Herbert Budka and Dickson, {Dennis W.} and Dugger, {Brittany N.} and Charles Duyckaerts and Isidro Ferrer and Forrest, {Shelley L.} and Ellen Gelpi and Gentleman, {Stephen M.} and Giorgio Giaccone and Grinberg, {Lea T.} and Halliday, {Glenda M.} and Hatanpaa, {Kimmo J.} and Hof, {Patrick R.} and Monika Hofer and Tibor Hortob{\'a}gyi and Ironside, {James W.} and Andrew King and Julia Kofler and Enik{\"o} K{\"o}vari and Kril, {Jillian J.} and Seth Love and Mackenzie, {Ian R.} and Qinwen Mao and Radoslav Matej and Catriona McLean and Munoz, {David G.} and Murray, {Melissa E.} and Janna Neltner and Nelson, {Peter T.} and Diane Ritchie and Rodriguez, {Roberta D.} and Zdenek Rohan and Annemieke Rozemuller and Kenji Sakai and Christian Schultz and Danielle Seilhean and Vanessa Smith and Pawel Tacik and Hitoshi Takahashi and Masaki Takao and {Rudolf Thal}, Dietmar and Serge Weis and Wharton, {Stephen B.} and White, {Charles L.} and Woulfe, {John M.} and Masahito Yamada and Trojanowski, {John Q.}",

year = "2017",

month = jul,

day = "15",

doi = "10.1093/jnen/nlx041",

language = "English",

volume = "76",

pages = "605--619",

journal = "Journal of Neuropathology and Experimental Neurology",

issn = "0022-3069",

publisher = "Lippincott Williams and Wilkins",

number = "7",

}

Kovacs, GG, Xie, SX, Lee, EB, Robinson, JL, Caswell, C, Irwin, DJ, Toledo, JB, Johnson, VE, Smith, DH, Alafuzoff, I, Attems, J, Bencze, J, Bieniek, KF, Bigio, EH, Bodi, I, Budka, H, Dickson, DW, Dugger, BN, Duyckaerts, C, Ferrer, I, Forrest, SL, Gelpi, E, Gentleman, SM, Giaccone, G, Grinberg, LT, Halliday, GM, Hatanpaa, KJ, Hof, PR, Hofer, M, Hortobágyi, T, Ironside, JW, King, A, Kofler, J, Kövari, E, Kril, JJ, Love, S, Mackenzie, IR, Mao, Q, Matej, R, McLean, C, Munoz, DG, Murray, ME, Neltner, J, Nelson, PT, Ritchie, D, Rodriguez, RD, Rohan, Z, Rozemuller, A, Sakai, K, Schultz, C, Seilhean, D, Smith, V, Tacik, P, Takahashi, H, Takao, M, Rudolf Thal, D, Weis, S, Wharton, SB, White, CL, Woulfe, JM, Yamada, M & Trojanowski, JQ 2017, 'Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)', Journal of Neuropathology and Experimental Neurology, vol. 76, no. 7, pp. 605-619. https://doi.org/10.1093/jnen/nlx041

TY - JOUR

T1 - Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

AU - Kovacs, Gabor G.

AU - Xie, Sharon X.

AU - Lee, Edward B.

AU - Robinson, John L.

AU - Caswell, Carrie

AU - Irwin, David J.

AU - Toledo, Jon B.

AU - Johnson, Victoria E.

AU - Smith, Douglas H.

AU - Alafuzoff, Irina

AU - Attems, Johannes

AU - Bencze, Janos

AU - Bieniek, Kevin F.

AU - Bigio, Eileen H.

AU - Bodi, Istvan

AU - Budka, Herbert

AU - Dickson, Dennis W.

AU - Dugger, Brittany N.

AU - Duyckaerts, Charles

AU - Ferrer, Isidro

AU - Forrest, Shelley L.

AU - Gelpi, Ellen

AU - Gentleman, Stephen M.

AU - Giaccone, Giorgio

AU - Grinberg, Lea T.

AU - Halliday, Glenda M.

AU - Hatanpaa, Kimmo J.

AU - Hof, Patrick R.

AU - Hofer, Monika

AU - Hortobágyi, Tibor

AU - Ironside, James W.

AU - King, Andrew

AU - Kofler, Julia

AU - Kövari, Enikö

AU - Kril, Jillian J.

AU - Love, Seth

AU - Mackenzie, Ian R.

AU - Mao, Qinwen

AU - Matej, Radoslav

AU - McLean, Catriona

AU - Munoz, David G.

AU - Murray, Melissa E.

AU - Neltner, Janna

AU - Nelson, Peter T.

AU - Ritchie, Diane

AU - Rodriguez, Roberta D.

AU - Rohan, Zdenek

AU - Rozemuller, Annemieke

AU - Sakai, Kenji

AU - Schultz, Christian

AU - Seilhean, Danielle

AU - Smith, Vanessa

AU - Tacik, Pawel

AU - Takahashi, Hitoshi

AU - Takao, Masaki

AU - Rudolf Thal, Dietmar

AU - Weis, Serge

AU - Wharton, Stephen B.

AU - White, Charles L.

AU - Woulfe, John M.

AU - Yamada, Masahito

AU - Trojanowski, John Q.

PY - 2017/7/15

Y1 - 2017/7/15

N2 - Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was >60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (>90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.

AB - Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was >60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (>90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.

KW - Aging

KW - ARTAG

KW - Digital pathology

KW - Interrater agreement

KW - Neuropathology

KW - Tau

KW - Tau-astrogliopathy

UR - http://www.scopus.com/inward/record.url?scp=85020517699&partnerID=8YFLogxK

U2 - 10.1093/jnen/nlx041

DO - 10.1093/jnen/nlx041

M3 - Article (Academic Journal)

C2 - 28591867

SN - 0022-3069

VL - 76

SP - 605

EP - 619

JO - Journal of Neuropathology and Experimental Neurology

JF - Journal of Neuropathology and Experimental Neurology

IS - 7

ER -

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

Abstract

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Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

Abstract

Research Groups and Themes

Keywords

Access to Document

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Other files and links

Fingerprint

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UKDP: Integrated DEmentiA Research environment (IDEA)

Cite this