Mutant insulin crystal packing

B. Xiao*, G. G. Dodson, E. J. Dodson, J. Clarkson, J. Turkenburg, U. Derewenda, L. Brady, J. Brange

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Abstract

A comparative study between mutant and native insulins in different crystal forms and structural conformations has revealed certain differences among these insulins in terms of crystal packing. In general, mutations involved in crystal contacts may cause change in the lattice organization. This change, however, may facilitate internal interactions in mutants. More work is needed before we are able to predict crystal growth by judging the effect of mutations on lattice contacts.

Original languageEnglish
Pages (from-to)144-151
Number of pages8
JournalJournal of Crystal Growth
Volume122
Issue number1-4
DOIs
Publication statusPublished - 2 Aug 1992

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