Mutant insulin crystal packing

B. Xiao; G. G. Dodson; E. J. Dodson; J. Clarkson; J. Turkenburg; U. Derewenda; L. Brady; J. Brange

doi:10.1016/0022-0248(92)90237-D

Mutant insulin crystal packing

B. Xiao^*, G. G. Dodson, E. J. Dodson, J. Clarkson, J. Turkenburg, U. Derewenda, L. Brady, J. Brange

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

A comparative study between mutant and native insulins in different crystal forms and structural conformations has revealed certain differences among these insulins in terms of crystal packing. In general, mutations involved in crystal contacts may cause change in the lattice organization. This change, however, may facilitate internal interactions in mutants. More work is needed before we are able to predict crystal growth by judging the effect of mutations on lattice contacts.

Original language	English
Pages (from-to)	144-151
Number of pages	8
Journal	Journal of Crystal Growth
Volume	122
Issue number	1-4
DOIs	https://doi.org/10.1016/0022-0248(92)90237-D
Publication status	Published - 2 Aug 1992

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title = "Mutant insulin crystal packing",

abstract = "A comparative study between mutant and native insulins in different crystal forms and structural conformations has revealed certain differences among these insulins in terms of crystal packing. In general, mutations involved in crystal contacts may cause change in the lattice organization. This change, however, may facilitate internal interactions in mutants. More work is needed before we are able to predict crystal growth by judging the effect of mutations on lattice contacts.",

author = "B. Xiao and Dodson, {G. G.} and Dodson, {E. J.} and J. Clarkson and J. Turkenburg and U. Derewenda and L. Brady and J. Brange",

year = "1992",

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doi = "10.1016/0022-0248(92)90237-D",

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T1 - Mutant insulin crystal packing

AU - Xiao, B.

AU - Dodson, G. G.

AU - Dodson, E. J.

AU - Clarkson, J.

AU - Turkenburg, J.

AU - Derewenda, U.

AU - Brady, L.

AU - Brange, J.

PY - 1992/8/2

Y1 - 1992/8/2

N2 - A comparative study between mutant and native insulins in different crystal forms and structural conformations has revealed certain differences among these insulins in terms of crystal packing. In general, mutations involved in crystal contacts may cause change in the lattice organization. This change, however, may facilitate internal interactions in mutants. More work is needed before we are able to predict crystal growth by judging the effect of mutations on lattice contacts.

AB - A comparative study between mutant and native insulins in different crystal forms and structural conformations has revealed certain differences among these insulins in terms of crystal packing. In general, mutations involved in crystal contacts may cause change in the lattice organization. This change, however, may facilitate internal interactions in mutants. More work is needed before we are able to predict crystal growth by judging the effect of mutations on lattice contacts.

UR - http://www.scopus.com/inward/record.url?scp=0027109266&partnerID=8YFLogxK

U2 - 10.1016/0022-0248(92)90237-D

DO - 10.1016/0022-0248(92)90237-D

M3 - Article (Academic Journal)

AN - SCOPUS:0027109266

SN - 0022-0248

VL - 122

SP - 144

EP - 151

JO - Journal of Crystal Growth

JF - Journal of Crystal Growth

IS - 1-4

ER -

Mutant insulin crystal packing

Abstract

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