Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomic acid B biosynthesis precedes pseudomonic acid A

J Hothersall; J Wu; AS Rahman; JA Shields; J Haddock; N Johnson; SM Cooper; ER Stephens; RJ Cox; J Crosby; CL Willis; TJ Simpson; CM Thomas

doi:10.1074/jbc.M701490200

Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomic acid B biosynthesis precedes pseudomonic acid A

J Hothersall, J Wu, AS Rahman, JA Shields, J Haddock, N Johnson, SM Cooper, ER Stephens, RJ Cox, J Crosby, CL Willis, TJ Simpson, CM Thomas

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

33 Citations (Scopus)

Translated title of the contribution	Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomic acid B biosynthesis precedes pseudomonic acid A
Original language	English
Pages (from-to)	15451 - 15461
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	282
Issue number	21
DOIs	https://doi.org/10.1074/jbc.M701490200
Publication status	Published - May 2007

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Publisher: Amer. Soc. Biochemistry Molecular Biology Inc

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STRUCTURAL AND MECHANISTIC STUDIES OF TYPE II POLYKETIDE SYNTHASES AND RELATED?
Simpson, T. J. (Principal Investigator)
1/02/04 → 1/06/07
Project: Research

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Hothersall, J., Wu, J., Rahman, AS., Shields, JA., Haddock, J., Johnson, N., Cooper, SM., Stephens, ER., Cox, RJ., Crosby, J., Willis, CL., Simpson, TJ., & Thomas, CM. (2007). Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomic acid B biosynthesis precedes pseudomonic acid A. Journal of Biological Chemistry, 282(21), 15451 - 15461. https://doi.org/10.1074/jbc.M701490200

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title = "Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomic acid B biosynthesis precedes pseudomonic acid A",

author = "J Hothersall and J Wu and AS Rahman and JA Shields and J Haddock and N Johnson and SM Cooper and ER Stephens and RJ Cox and J Crosby and CL Willis and TJ Simpson and CM Thomas",

note = "Publisher: Amer. Soc. Biochemistry Molecular Biology Inc",

year = "2007",

month = may,

doi = "10.1074/jbc.M701490200",

language = "English",

volume = "282",

pages = "15451 -- 15461",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "21",

}

Hothersall, J, Wu, J, Rahman, AS, Shields, JA, Haddock, J, Johnson, N, Cooper, SM, Stephens, ER, Cox, RJ, Crosby, J , Willis, CL, Simpson, TJ & Thomas, CM 2007, 'Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomic acid B biosynthesis precedes pseudomonic acid A', Journal of Biological Chemistry, vol. 282, no. 21, pp. 15451 - 15461. https://doi.org/10.1074/jbc.M701490200

Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomic acid B biosynthesis precedes pseudomonic acid A. / Hothersall, J; Wu, J; Rahman, AS et al.
In: Journal of Biological Chemistry, Vol. 282, No. 21, 05.2007, p. 15451 - 15461.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomic acid B biosynthesis precedes pseudomonic acid A

AU - Hothersall, J

AU - Wu, J

AU - Rahman, AS

AU - Shields, JA

AU - Haddock, J

AU - Johnson, N

AU - Cooper, SM

AU - Stephens, ER

AU - Cox, RJ

AU - Crosby, J

AU - Willis, CL

AU - Simpson, TJ

AU - Thomas, CM

N1 - Publisher: Amer. Soc. Biochemistry Molecular Biology Inc

PY - 2007/5

Y1 - 2007/5

U2 - 10.1074/jbc.M701490200

DO - 10.1074/jbc.M701490200

M3 - Article (Academic Journal)

C2 - 17383964

SN - 0021-9258

VL - 282

SP - 15451

EP - 15461

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 21

ER -

Hothersall J, Wu J, Rahman AS, Shields JA, Haddock J, Johnson N et al. Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomic acid B biosynthesis precedes pseudomonic acid A. Journal of Biological Chemistry. 2007 May;282(21):15451 - 15461. doi: 10.1074/jbc.M701490200

Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomic acid B biosynthesis precedes pseudomonic acid A

Bibliographical note

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STRUCTURAL AND MECHANISTIC STUDIES OF TYPE II POLYKETIDE SYNTHASES AND RELATED?

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