Projects per year
Abstract
Aminoglycoside resistance in Stenotrophomonas maltophilia is multifactorial, but the most significant mechanism is overproduction of the SmeYZ efflux system. By studying laboratory selected mutants and clinical isolates, we show here that damage to the 50S Ribosomal protein L1 (RplA) activates SmeYZ production. We also show that gentamicin and minocycline, which target the ribosome, induce expression of smeYZ These findings explain the role of SmeYZ in both intrinsic and mutationally acquired aminoglycoside resistance.
Original language | English |
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Article number | e01524-19 |
Number of pages | 5 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 64 |
Issue number | 2 |
DOIs | |
Publication status | Published - 27 Jan 2020 |
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Dive into the research topics of 'Mutations in Ribosomal Protein RplA or Treatment with Ribosomal Acting Antibiotics Activate Production of Aminoglycoside Efflux Pump SmeYZ in Stenotrophomonas maltophilia'. Together they form a unique fingerprint.Projects
- 2 Finished
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One Health Drivers of Antibacterial Resistance in Thailand
Avison, M. B. (Principal Investigator), Lambert, H. S. (Co-Investigator) & Al Husein, N. (Researcher)
1/05/18 → 31/01/22
Project: Research
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FEC 202022 - Detecting antibiotic resistance proteins in clinical samples using proteomics.
Avison, M. B. (Principal Investigator)
13/04/16 → 12/10/17
Project: Research