Myocardial T1 mapping

Heerajnarain Bulluck, Viviana Maestrini, Stefania Rosmini, Amna Abdel-Gadir, Thomas A Treibel, Silvia Castelletti, Chiara Bucciarelli-Ducci, Charlotte Manisty, James C Moon

Research output: Contribution to journalArticle (Academic Journal)peer-review

50 Citations (Scopus)

Abstract

Cardiovascular magnetic resonance is a well-established tool for the quantification of focal fibrosis. With the introduction of T1 mapping, diffuse myocardial processes can be detected and quantified. In particular, infiltration and storage disorders with large disease-related changes, and diffuse fibrosis where measurement is harder but the potential impact larger. This has added a new dimension to the understanding and assessment of various myocardial diseases. T1 mapping promises to detect early disease, quantify disease severity and provide prognostic insights into certain conditions. It also has the potential to be a robust surrogate marker in drug development trials to monitor therapeutic response and be a prognostic marker in certain diseases. T1 mapping is an evolving field and numerous factors currently preclude its standardization. In this review, we describe the current status of T1 mapping and its potential promises and pitfalls.

Original languageEnglish
Pages (from-to)487-94
Number of pages8
JournalCirculation Research
Volume79
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • Fibrosis
  • Heart
  • Heart Diseases
  • Humans
  • Magnetic Resonance Imaging
  • Monitoring, Physiologic
  • Myocardium

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