Myocardial tissue characterization by cardiac magnetic resonance imaging using T1 mapping predicts ventricular arrhythmia in ischemic and non-ischemic cardiomyopathy patients with implantable cardioverter-defibrillators

Zhong Chen, Manav Sohal, Tobias Voigt, Eva Sammut, Catalina Tobon-Gomez, Nick Child, Tom Jackson, Anoop Shetty, Julian Bostock, Michael Cooklin, Mark O'Neill, Matthew Wright, Francis Murgatroyd, Jaswinder Gill, Gerry Carr-White, Amedeo Chiribiri, Tobias Schaeffter, Reza Razavi, C Aldo Rinaldi

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

BACKGROUND: Diffuse myocardial fibrosis may provide a substrate for the initiation and maintenance of ventricular arrhythmia. T1 mapping overcomes the limitations of the conventional delayed contrast-enhanced cardiac magnetic resonance (CE-CMR) imaging technique by allowing quantification of diffuse fibrosis.

OBJECTIVE: The purpose of this study was to assess whether myocardial tissue characterization using T1 mapping would predict ventricular arrhythmia in ischemic and non-ischemic cardiomyopathies.

METHODS: This was a prospective longitudinal study of consecutive patients receiving implantable cardioverter-defibrillators in a tertiary cardiac center. Participants underwent CMR myocardial tissue characterization using T1 mapping and conventional CE-CMR scar assessment before device implantation. The primary end point was an appropriate implantable cardioverter-defibrillator therapy or documented sustained ventricular arrhythmia.

RESULTS: One hundred thirty patients (71 ischemic and 59 non-ischemic) were included with a mean follow-up period of 430 ± 185 days (median 425 days; interquartile range 293 days). At follow-up, 23 patients (18%) experienced the primary end point. In multivariable-adjusted analyses, the following factors showed a significant association with the primary end point: secondary prevention (hazard ratio [HR] 1.70; 95% confidence interval [95% CI] 1.01-1.91), noncontrast T1(_native) for every 10-ms increment in value (HR 1.10; CI 1.04-1.16; 90-ms difference between the end point-positive and end point-negative groups), and Grayzone(_2sd-3sd) for every 1% left ventricular increment in value (HR 1.36; CI 1.15-1.61; 4% difference between the end point-positive and end point-negative groups). Other CE-CMR indices including Scar(_2sd), Scar(_FWHM), and Grayzone(_2sd-FWHM) were also significantly, even though less strongly, associated with the primary end point as compared with Grayzone(_2sd-3sd).

CONCLUSION: Quantitative myocardial tissue assessment using T1 mapping is an independent predictor of ventricular arrhythmia in both ischemic and non-ischemic cardiomyopathies.

Original languageEnglish
Pages (from-to)792-801
Number of pages10
JournalHeart Rhythm
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2015

Bibliographical note

Copyright © 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Keywords

  • Adult
  • Aged
  • Cardiomyopathies/complications
  • Death, Sudden, Cardiac/prevention & control
  • Defibrillators, Implantable
  • Female
  • Fibrosis
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging, Cine/methods
  • Male
  • Middle Aged
  • Myocardium/pathology
  • Predictive Value of Tests
  • Prognosis
  • Prospective Studies
  • Secondary Prevention
  • Tachycardia, Ventricular/diagnosis
  • United Kingdom

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