N-H carbazole synthesis from 2-chloroanilines via consecutive amination and C-H activation

RB Bedford, M Betham

Research output: Contribution to journalArticle (Academic Journal)peer-review

150 Citations (Scopus)

Abstract

N-H carbazoles can be produced from 2-chloroanilines and aryl bromides via consecutive catalytic amination and C-H activation. In many instances, this can be done in a tandem manner in one pot. The methodologies developed can be used in the synthesis of a range of carbazoles, including the natural products Clausine P and glycozolidine and a precursor in the synthesis of Clausines H, K, O, and 7-methoxy-O-methylmukonal, and can be extended to the synthesis of indoles.
Translated title of the contributionN-H carbazole synthesis from 2-chloroanilines via consecutive amination and C-H activation
Original languageEnglish
Pages (from-to)9403 - 9410
Number of pages8
JournalJournal of Organic Chemistry
Volume71 (25)
DOIs
Publication statusPublished - Dec 2006

Bibliographical note

Publisher: American Chemical Society

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