N- versus C-terminal control over the screw-sense preference of the configurationally achiral, conformationally helical peptide motif Aib 8GlyAib8

Jordi Solà; Madeleine Helliwell; Jonathan Clayden

doi:10.1021/ja100662d

N- versus C-terminal control over the screw-sense preference of the configurationally achiral, conformationally helical peptide motif Aib 8GlyAib8

Jordi Solà, Madeleine Helliwell, Jonathan Clayden^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

64 Citations (Scopus)

Abstract

Conformational control over the screw sense of a helical 17-mer of achiral amino acids, Aib₈GlyAib₈, from a single chiral residue located at the N-terminus is better than that from a single amino acid located at the C-terminus. X-ray crystallography indicates that Aib ₈GlyAib₈ forms the longest 3₁₀ helical structure observed crystallographically to date.

Original language	English
Pages (from-to)	4548-4549
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	132
Issue number	13
Early online date	16 Mar 2010
DOIs	https://doi.org/10.1021/ja100662d
Publication status	Published - 7 Apr 2010

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title = "N- versus C-terminal control over the screw-sense preference of the configurationally achiral, conformationally helical peptide motif Aib 8GlyAib8",

abstract = "Conformational control over the screw sense of a helical 17-mer of achiral amino acids, Aib8GlyAib8, from a single chiral residue located at the N-terminus is better than that from a single amino acid located at the C-terminus. X-ray crystallography indicates that Aib 8GlyAib8 forms the longest 310 helical structure observed crystallographically to date.",

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N- versus C-terminal control over the screw-sense preference of the configurationally achiral, conformationally helical peptide motif Aib 8GlyAib8. / Solà, Jordi; Helliwell, Madeleine; Clayden, Jonathan.
In: Journal of the American Chemical Society, Vol. 132, No. 13, 07.04.2010, p. 4548-4549.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - N- versus C-terminal control over the screw-sense preference of the configurationally achiral, conformationally helical peptide motif Aib 8GlyAib8

AU - Solà, Jordi

AU - Helliwell, Madeleine

AU - Clayden, Jonathan

PY - 2010/4/7

Y1 - 2010/4/7

N2 - Conformational control over the screw sense of a helical 17-mer of achiral amino acids, Aib8GlyAib8, from a single chiral residue located at the N-terminus is better than that from a single amino acid located at the C-terminus. X-ray crystallography indicates that Aib 8GlyAib8 forms the longest 310 helical structure observed crystallographically to date.

AB - Conformational control over the screw sense of a helical 17-mer of achiral amino acids, Aib8GlyAib8, from a single chiral residue located at the N-terminus is better than that from a single amino acid located at the C-terminus. X-ray crystallography indicates that Aib 8GlyAib8 forms the longest 310 helical structure observed crystallographically to date.

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U2 - 10.1021/ja100662d

DO - 10.1021/ja100662d

M3 - Article (Academic Journal)

C2 - 20232805

AN - SCOPUS:77950845978

SN - 0002-7863

VL - 132

SP - 4548

EP - 4549

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 13

ER -

N- versus C-terminal control over the screw-sense preference of the configurationally achiral, conformationally helical peptide motif Aib 8GlyAib8

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