N- versus C-terminal control over the screw-sense preference of the configurationally achiral, conformationally helical peptide motif Aib 8GlyAib8

Jordi Solà, Madeleine Helliwell, Jonathan Clayden*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

56 Citations (Scopus)

Abstract

Conformational control over the screw sense of a helical 17-mer of achiral amino acids, Aib8GlyAib8, from a single chiral residue located at the N-terminus is better than that from a single amino acid located at the C-terminus. X-ray crystallography indicates that Aib 8GlyAib8 forms the longest 310 helical structure observed crystallographically to date.

Original languageEnglish
Pages (from-to)4548-4549
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number13
Early online date16 Mar 2010
DOIs
Publication statusPublished - 7 Apr 2010

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