Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection

Laura Rodríguez-Pérez, Javier Ramos-Soriano, Alfonso Pérez-Sánchez, Beatriz M. Illescas*, Antonio Muñoz, Joanna Luczkowiak, Fátima Lasala, Javier Rojo, Rafael Delgado, Nazario Martín

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

20 Citations (Scopus)

Abstract

SWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC "click chemistry" approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.

Original languageEnglish
Pages (from-to)9891-9898
Number of pages8
JournalJournal of the American Chemical Society
Volume140
Issue number31
Early online date17 Jul 2018
DOIs
Publication statusPublished - 8 Aug 2018

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