Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection

Laura Rodríguez-Pérez; Javier Ramos-Soriano; Alfonso Pérez-Sánchez; Beatriz M. Illescas; Antonio Muñoz; Joanna Luczkowiak; Fátima Lasala; Javier Rojo; Rafael Delgado; Nazario Martín

doi:10.1021/jacs.8b03847

Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection

Laura Rodríguez-Pérez, Javier Ramos-Soriano, Alfonso Pérez-Sánchez, Beatriz M. Illescas^*, Antonio Muñoz, Joanna Luczkowiak, Fátima Lasala, Javier Rojo, Rafael Delgado, Nazario Martín

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

SWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC "click chemistry" approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.

Original language	English
Pages (from-to)	9891-9898
Number of pages	8
Journal	Journal of the American Chemical Society
Volume	140
Issue number	31
Early online date	17 Jul 2018
DOIs	https://doi.org/10.1021/jacs.8b03847
Publication status	Published - 8 Aug 2018

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title = "Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection",

abstract = "SWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC {"}click chemistry{"} approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.",

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AU - Rodríguez-Pérez, Laura

AU - Ramos-Soriano, Javier

AU - Pérez-Sánchez, Alfonso

AU - Illescas, Beatriz M.

AU - Muñoz, Antonio

AU - Luczkowiak, Joanna

AU - Lasala, Fátima

AU - Rojo, Javier

AU - Delgado, Rafael

AU - Martín, Nazario

PY - 2018/8/8

Y1 - 2018/8/8

N2 - SWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC "click chemistry" approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.

AB - SWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC "click chemistry" approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.

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M3 - Article (Academic Journal)

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Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection

Abstract

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