Nanometer-range communication of stereochemical information by reversible switching of molecular helicity

Jordi Solá*, Stephen P. Fletcher, Alejandro Castellanos, Jonathan Clayden

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

52 Citations (Scopus)

Abstract

(Figure Presented) A long-distance call: The inversion of configuration at a stereogenic center led to a detectable switch in the position of a 13C stereochemical probe 40 bonds (2.5 nm) away. Information was relayed between the sites by an inversion of screw sense in the intervening helix as illustrated (13C NMR signals were read as output).

Original languageEnglish
Pages (from-to)6836-6839
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number38
Early online date4 Aug 2010
DOIs
Publication statusPublished - 10 Sep 2010

Keywords

  • Conformation analysis
  • Helicity
  • Molecular switches
  • Nanotechnology
  • Signal transduction

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