Nanometer-range communication of stereochemical information by reversible switching of molecular helicity

Jordi Solá; Stephen P. Fletcher; Alejandro Castellanos; Jonathan Clayden

doi:10.1002/anie.201001130

Nanometer-range communication of stereochemical information by reversible switching of molecular helicity

Jordi Solá^*, Stephen P. Fletcher, Alejandro Castellanos, Jonathan Clayden

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

62 Citations (Scopus)

Abstract

(Figure Presented) A long-distance call: The inversion of configuration at a stereogenic center led to a detectable switch in the position of a ¹³C stereochemical probe 40 bonds (2.5 nm) away. Information was relayed between the sites by an inversion of screw sense in the intervening helix as illustrated (¹³C NMR signals were read as output).

Original language	English
Pages (from-to)	6836-6839
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	38
Early online date	4 Aug 2010
DOIs	https://doi.org/10.1002/anie.201001130
Publication status	Published - 10 Sep 2010

Keywords

Conformation analysis
Helicity
Molecular switches
Nanotechnology
Signal transduction

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abstract = "(Figure Presented) A long-distance call: The inversion of configuration at a stereogenic center led to a detectable switch in the position of a 13C stereochemical probe 40 bonds (2.5 nm) away. Information was relayed between the sites by an inversion of screw sense in the intervening helix as illustrated (13C NMR signals were read as output).",

keywords = "Conformation analysis, Helicity, Molecular switches, Nanotechnology, Signal transduction",

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T1 - Nanometer-range communication of stereochemical information by reversible switching of molecular helicity

AU - Solá, Jordi

AU - Fletcher, Stephen P.

AU - Castellanos, Alejandro

AU - Clayden, Jonathan

PY - 2010/9/10

Y1 - 2010/9/10

N2 - (Figure Presented) A long-distance call: The inversion of configuration at a stereogenic center led to a detectable switch in the position of a 13C stereochemical probe 40 bonds (2.5 nm) away. Information was relayed between the sites by an inversion of screw sense in the intervening helix as illustrated (13C NMR signals were read as output).

AB - (Figure Presented) A long-distance call: The inversion of configuration at a stereogenic center led to a detectable switch in the position of a 13C stereochemical probe 40 bonds (2.5 nm) away. Information was relayed between the sites by an inversion of screw sense in the intervening helix as illustrated (13C NMR signals were read as output).

KW - Conformation analysis

KW - Helicity

KW - Molecular switches

KW - Nanotechnology

KW - Signal transduction

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U2 - 10.1002/anie.201001130

DO - 10.1002/anie.201001130

M3 - Article (Academic Journal)

C2 - 20687056

AN - SCOPUS:77956589648

VL - 49

SP - 6836

EP - 6839

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 38

ER -

Nanometer-range communication of stereochemical information by reversible switching of molecular helicity

Abstract

Keywords

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