Narrow QRS systolic heart failure: is there a target for cardiac resynchronization?

Tom Jackson, Simon Claridge, Jonathan Behar, Eva Sammut, Jessica Webb, Gerald Carr-White, Reza Razavi, Christopher Aldo Rinaldi

Research output: Contribution to journalArticle (Academic Journal)peer-review

4 Citations (Scopus)


Cardiac resynchronization therapy has revolutionized the management of systolic heart failure in patients with prolonged QRS during the past 20 years. Initially, the use of this treatment in patients with shorter QRS durations showed promising results, which have since been opposed by larger randomized controlled trials. Despite this, some questions remain, such as, whether correction of mechanical dyssynchrony is the therapeutic target by which biventricular pacing may confer benefit in this group, or are there other mechanisms that need consideration? In addition, novel techniques of cardiac resynchronization therapy delivery such as endocardial and multisite pacing may reduce potential detrimental effects of biventricular pacing, thereby improving the benefit/harm balance of this therapy in some patients.

Original languageEnglish
Pages (from-to)783-97
Number of pages15
JournalExpert Review of Cardiovascular Therapy
Issue number7
Publication statusPublished - 2015


  • Cardiac Resynchronization Therapy
  • Electrocardiography
  • Heart Failure, Systolic/therapy
  • Humans
  • Ventricular Dysfunction/diagnosis


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