National Study of Acute Stroke in Patients on Renal Replacement Therapies

Albert Power, Reetha Steenkamp, James Fotheringham, Damian Fogarty

Research output: Contribution to conferenceConference Posterpeer-review


Background: Stroke in patients on renal replacement therapy [RRT] remains poorly studied especially in peritoneal dialysis [PD] & transplant cohorts and particularly in Europe. We therefore conducted a national study to characterize the distribution and impact of stroke in all RRT patients. Methods: We studied all patients incident to RRT in England [Jan 2002–Dec 2006] with follow up to Dec 2009 [n=21175, 62% male, 47% diabetic, 74% hemodialysis, 23% PD]. Demography & comorbidity at the start of RRT and hospitalization for first acute stroke were derived from ICD-10 codes in national Hospital Episode Statistic [HES] datasets linked to UK Renal Registry data. Results: Overall 12% of the study cohort [n=2484] experienced fi rst acute stroke [40% events prior to RRT start] compared to 2.3% in the general population. During RRT, 77% strokes occurred in hemodialysis [HD], 16% on PD & 4% in renal transplant patients. Acute stroke patients were older [mean 65.9 vs 60.3yrs, p<0.001] with 62% strokes clustering in those >65yrs old. Stroke associated with cardiac & peripheral arterial disease [p<0.001], diabetes [p<0.001], and especially prior cerebrovascular disease [51% vs 7%, p<0.001]. There was no association between stroke and ethnicity [p=0.5], health network area [p=0.6] or social deprivation [Townsend index, p=0.1] with a trend to more events in females [p=0.08] in keeping with UK population data. Conclusions: Stroke affects a signifi cant proportion of patients on all RRT modalities and remains over-represented in dialysis cohorts particularly HD. Current ongoing analyses of national patient- & treatment-level stroke risk factors will allow for interventions to reduce stroke burden in all RRT populations.
Original languageEnglish
Number of pages1
Publication statusPublished - 2013
EventAmerican Society of Nephrology, Kidney Week 2013 - GA, Atlanta, United States
Duration: 5 Nov 201310 Nov 2013


ConferenceAmerican Society of Nephrology, Kidney Week 2013
CountryUnited States

Fingerprint Dive into the research topics of 'National Study of Acute Stroke in Patients on Renal Replacement Therapies'. Together they form a unique fingerprint.

Cite this