Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults

Kondwani C Jambo, Enoch Sepako, Sarah J Glennie, David Mzinza, Neil A Williams, Stephen B Gordon, Robert S Heyderman

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Abstract

Seasonal influenza has been associated with greater morbidity and mortality in AIDS patients. Highly-active antiretroviral therapy (HAART) has led to some reduction in influenza-related complications but the nature of naturally-acquired T-cell immunity to influenza virus in an African setting, and how this changes with immune reconstitution following HAART is unknown. We measured influenza-specific CD4(+) T-cell immunity in unimmunized HIV-infected Malawian adults and then investigated immune reconstitution following HAART.
Original languageEnglish
Pages (from-to)e38628
JournalPLoS ONE
Volume7
Issue number6
DOIs
Publication statusPublished - 2012

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    Jambo, K. C., Sepako, E., Glennie, S. J., Mzinza, D., Williams, N. A., Gordon, S. B., & Heyderman, R. S. (2012). Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults. PLoS ONE, 7(6), e38628. https://doi.org/10.1371/journal.pone.0038628