Seasonal influenza has been associated with greater morbidity and mortality in AIDS patients. Highly-active antiretroviral therapy (HAART) has led to some reduction in influenza-related complications but the nature of naturally-acquired T-cell immunity to influenza virus in an African setting, and how this changes with immune reconstitution following HAART is unknown. We measured influenza-specific CD4(+) T-cell immunity in unimmunized HIV-infected Malawian adults and then investigated immune reconstitution following HAART.
Jambo, K. C., Sepako, E., Glennie, S. J., Mzinza, D., Williams, N. A., Gordon, S. B., & Heyderman, R. S. (2012). Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults. PLoS ONE, 7(6), e38628. https://doi.org/10.1371/journal.pone.0038628