Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults

Kondwani C Jambo; Enoch Sepako; Sarah J Glennie; David Mzinza; Neil A Williams; Stephen B Gordon; Robert S Heyderman

doi:10.1371/journal.pone.0038628

Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults

Kondwani C Jambo, Enoch Sepako, Sarah J Glennie, David Mzinza, Neil A Williams, Stephen B Gordon, Robert S Heyderman

Research output: Contribution to journal › Article (Academic Journal) › peer-review

7 Citations (Scopus)

Abstract

Seasonal influenza has been associated with greater morbidity and mortality in AIDS patients. Highly-active antiretroviral therapy (HAART) has led to some reduction in influenza-related complications but the nature of naturally-acquired T-cell immunity to influenza virus in an African setting, and how this changes with immune reconstitution following HAART is unknown. We measured influenza-specific CD4(+) T-cell immunity in unimmunized HIV-infected Malawian adults and then investigated immune reconstitution following HAART.

Original language	English
Pages (from-to)	e38628
Journal	PLOS ONE
Volume	7
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0038628
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pone.0038628

Handle.net

Persistent link

Cite this

@article{f6278d38bb4a4f5c99f5a64e45a4eabd,

title = "Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults",

abstract = "Seasonal influenza has been associated with greater morbidity and mortality in AIDS patients. Highly-active antiretroviral therapy (HAART) has led to some reduction in influenza-related complications but the nature of naturally-acquired T-cell immunity to influenza virus in an African setting, and how this changes with immune reconstitution following HAART is unknown. We measured influenza-specific CD4(+) T-cell immunity in unimmunized HIV-infected Malawian adults and then investigated immune reconstitution following HAART.",

author = "Jambo, \{Kondwani C\} and Enoch Sepako and Glennie, \{Sarah J\} and David Mzinza and Williams, \{Neil A\} and Gordon, \{Stephen B\} and Heyderman, \{Robert S\}",

year = "2012",

doi = "10.1371/journal.pone.0038628",

language = "English",

volume = "7",

pages = "e38628",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "6",

}

TY - JOUR

T1 - Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults

AU - Jambo, Kondwani C

AU - Sepako, Enoch

AU - Glennie, Sarah J

AU - Mzinza, David

AU - Williams, Neil A

AU - Gordon, Stephen B

AU - Heyderman, Robert S

PY - 2012

Y1 - 2012

N2 - Seasonal influenza has been associated with greater morbidity and mortality in AIDS patients. Highly-active antiretroviral therapy (HAART) has led to some reduction in influenza-related complications but the nature of naturally-acquired T-cell immunity to influenza virus in an African setting, and how this changes with immune reconstitution following HAART is unknown. We measured influenza-specific CD4(+) T-cell immunity in unimmunized HIV-infected Malawian adults and then investigated immune reconstitution following HAART.

AB - Seasonal influenza has been associated with greater morbidity and mortality in AIDS patients. Highly-active antiretroviral therapy (HAART) has led to some reduction in influenza-related complications but the nature of naturally-acquired T-cell immunity to influenza virus in an African setting, and how this changes with immune reconstitution following HAART is unknown. We measured influenza-specific CD4(+) T-cell immunity in unimmunized HIV-infected Malawian adults and then investigated immune reconstitution following HAART.

U2 - 10.1371/journal.pone.0038628

DO - 10.1371/journal.pone.0038628

M3 - Article (Academic Journal)

C2 - 22715399

SN - 1932-6203

VL - 7

SP - e38628

JO - PLOS ONE

JF - PLOS ONE

IS - 6

ER -

Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults

Abstract

UN SDGs

Access to Document

Handle.net

Fingerprint

Cite this