Neither Xenon nor Fentanyl Induces Neuroapoptosis in the Newborn Pig Brain

Hemmen Sabir, Sarah Bishop, Nicki Cohen, Elke Maes, Xun Liu, John Dingley, Marianne Thoresen

Research output: Contribution to journalArticle (Academic Journal)peer-review

27 Citations (Scopus)

Abstract

BACKGROUND:: Some inhalation anesthetics increase apoptotic cell death in the developing brain. Xenon, an inhalation anesthetic, increases neuroprotection when combined with therapeutic hypothermia after hypoxic-ischemic brain injury in newborn animals. The authors, therefore, examined whether there was any neuroapoptotic effect of breathing 50% xenon with continuous fentanyl sedation for 24 h at normothermia or hypothermia on newborn pigs. METHODS:: Twenty-six healthy pigs (
Original languageEnglish
JournalAnesthesiology
DOIs
Publication statusPublished - 12 Apr 2013

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