Neither Xenon nor Fentanyl Induces Neuroapoptosis in the Newborn Pig Brain

Hemmen Sabir; Sarah Bishop; Nicki Cohen; Elke Maes; Xun Liu; John Dingley; Marianne Thoresen

doi:10.1097/ALN.0b013e318294934d

Neither Xenon nor Fentanyl Induces Neuroapoptosis in the Newborn Pig Brain

Hemmen Sabir
, Sarah Bishop
, Nicki Cohen
, Elke Maes
, Xun Liu
, John Dingley
, Marianne Thoresen

Research output: Contribution to journal › Article (Academic Journal) › peer-review

40 Citations (Scopus)

Abstract

BACKGROUND:: Some inhalation anesthetics increase apoptotic cell death in the developing brain. Xenon, an inhalation anesthetic, increases neuroprotection when combined with therapeutic hypothermia after hypoxic-ischemic brain injury in newborn animals. The authors, therefore, examined whether there was any neuroapoptotic effect of breathing 50% xenon with continuous fentanyl sedation for 24 h at normothermia or hypothermia on newborn pigs. METHODS:: Twenty-six healthy pigs (

Original language	English
Journal	Anesthesiology
DOIs	https://doi.org/10.1097/ALN.0b013e318294934d
Publication status	Published - 12 Apr 2013

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title = "Neither Xenon nor Fentanyl Induces Neuroapoptosis in the Newborn Pig Brain",

abstract = "BACKGROUND:: Some inhalation anesthetics increase apoptotic cell death in the developing brain. Xenon, an inhalation anesthetic, increases neuroprotection when combined with therapeutic hypothermia after hypoxic-ischemic brain injury in newborn animals. The authors, therefore, examined whether there was any neuroapoptotic effect of breathing 50\% xenon with continuous fentanyl sedation for 24 h at normothermia or hypothermia on newborn pigs. METHODS:: Twenty-six healthy pigs (",

author = "Hemmen Sabir and Sarah Bishop and Nicki Cohen and Elke Maes and Xun Liu and John Dingley and Marianne Thoresen",

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T1 - Neither Xenon nor Fentanyl Induces Neuroapoptosis in the Newborn Pig Brain

AU - Sabir, Hemmen

AU - Bishop, Sarah

AU - Cohen, Nicki

AU - Maes, Elke

AU - Liu, Xun

AU - Dingley, John

AU - Thoresen, Marianne

PY - 2013/4/12

Y1 - 2013/4/12

N2 - BACKGROUND:: Some inhalation anesthetics increase apoptotic cell death in the developing brain. Xenon, an inhalation anesthetic, increases neuroprotection when combined with therapeutic hypothermia after hypoxic-ischemic brain injury in newborn animals. The authors, therefore, examined whether there was any neuroapoptotic effect of breathing 50% xenon with continuous fentanyl sedation for 24 h at normothermia or hypothermia on newborn pigs. METHODS:: Twenty-six healthy pigs (

AB - BACKGROUND:: Some inhalation anesthetics increase apoptotic cell death in the developing brain. Xenon, an inhalation anesthetic, increases neuroprotection when combined with therapeutic hypothermia after hypoxic-ischemic brain injury in newborn animals. The authors, therefore, examined whether there was any neuroapoptotic effect of breathing 50% xenon with continuous fentanyl sedation for 24 h at normothermia or hypothermia on newborn pigs. METHODS:: Twenty-six healthy pigs (

U2 - 10.1097/ALN.0b013e318294934d

DO - 10.1097/ALN.0b013e318294934d

M3 - Article (Academic Journal)

C2 - 23591070

SN - 1528-1175

JO - Anesthesiology

JF - Anesthesiology

ER -

Neither Xenon nor Fentanyl Induces Neuroapoptosis in the Newborn Pig Brain

Abstract

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