Neural mechanisms of attending to items in working memory

Sanjay G. Manohar, Nahid Zokaei, Sean J. Fallon, Tim P. Vogels, Masud Husain

Research output: Contribution to journalArticle (Academic Journal)peer-review

214 Downloads (Pure)

Abstract

Working memory, the ability to keep recently accessed information available for immediate manipulation, has been proposed to rely on two mechanisms that appear difficult to reconcile: self-sustained neural firing, or the opposite—activity-silent synaptic traces. Here we review and contrast models of these two mechanisms, and then show that both phenomena can co-exist within a unified system in which neurons hold information in both activity and synapses. Rapid plasticity in flexibly-coding neurons allows features to be bound together into objects, with an important emergent property being the focus of attention. One memory item is held by persistent activity in an attended or “focused” state, and is thus remembered better than other items. Other, previously attended items can remain in memory but in the background, encoded in activity-silent synaptic traces. This dual functional architecture provides a unified common mechanism accounting for a diversity of perplexing attention and memory effects that have been hitherto difficult to explain in a single theoretical framework.
Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalNeuroscience and Biobehavioral Reviews
Volume101
Early online date26 Mar 2019
DOIs
Publication statusPublished - 1 Jun 2019

Keywords

  • working memory
  • attention
  • neural networks
  • Hebbian plasticity
  • attractor network

Fingerprint Dive into the research topics of 'Neural mechanisms of attending to items in working memory'. Together they form a unique fingerprint.

Cite this