Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link?

Matthew J Cates; C John Dickinson; Emma C J Hart; Julian F R Paton

doi:10.1007/s11906-012-0267-6

Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link?

Matthew J Cates, C John Dickinson, Emma C J Hart, Julian F R Paton

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Abstract

There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.

Original language	English
Pages (from-to)	261-9
Number of pages	9
Journal	Current Hypertension Reports
Volume	14
Issue number	3
DOIs	https://doi.org/10.1007/s11906-012-0267-6
Publication status	Published - Jun 2012

Keywords

Animals
Basilar Artery
Brain Stem
Humans
Hypertension
Rats
Rats, Inbred SHR
Sympathetic Nervous System
Vascular Resistance
Vertebral Artery

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title = "Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link?",

abstract = "There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.",

keywords = "Animals, Basilar Artery, Brain Stem, Humans, Hypertension, Rats, Rats, Inbred SHR, Sympathetic Nervous System, Vascular Resistance, Vertebral Artery",

author = "Cates, {Matthew J} and Dickinson, {C John} and Hart, {Emma C J} and Paton, {Julian F R}",

year = "2012",

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TY - JOUR

T1 - Neurogenic hypertension and elevated vertebrobasilar arterial resistance

T2 - is there a causative link?

AU - Cates, Matthew J

AU - Dickinson, C John

AU - Hart, Emma C J

AU - Paton, Julian F R

PY - 2012/6

Y1 - 2012/6

N2 - There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.

AB - There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.

KW - Animals

KW - Basilar Artery

KW - Brain Stem

KW - Humans

KW - Hypertension

KW - Rats

KW - Rats, Inbred SHR

KW - Sympathetic Nervous System

KW - Vascular Resistance

KW - Vertebral Artery

U2 - 10.1007/s11906-012-0267-6

DO - 10.1007/s11906-012-0267-6

M3 - Article (Academic Journal)

C2 - 22562144

SN - 1522-6417

VL - 14

SP - 261

EP - 269

JO - Current Hypertension Reports

JF - Current Hypertension Reports

IS - 3

ER -

Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link?

Abstract

Keywords

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