Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link?

Matthew J Cates, C John Dickinson, Emma C J Hart, Julian F R Paton

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

Abstract

There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.

Original languageEnglish
Pages (from-to)261-9
Number of pages9
JournalCurrent Hypertension Reports
Volume14
Issue number3
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Animals
  • Basilar Artery
  • Brain Stem
  • Humans
  • Hypertension
  • Rats
  • Rats, Inbred SHR
  • Sympathetic Nervous System
  • Vascular Resistance
  • Vertebral Artery

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