Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit

Luke Prince; Travis J Bacon; Cezar Tigaret; Jack Mellor

doi:10.3389/fnsyn.2016.00032

Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit

Luke Prince, Travis J Bacon, Cezar Tigaret, Jack Mellor

Research output: Contribution to journal › Article (Academic Journal) › peer-review

30 Citations (Scopus)

400 Downloads (Pure)

Abstract

The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.

Original language	English
Article number	32
Number of pages	16
Journal	Frontiers in Synaptic Neuroscience
Volume	8
DOIs	https://doi.org/10.3389/fnsyn.2016.00032
Publication status	Published - 17 Oct 2016

Bibliographical note

20 September 2016

Keywords

acetylcholine
noradrenaline
Serotonin
dopamine
dentate gyrus
CA3
hippocampal
mossy fibers
computational modeling

Access to Document

10.3389/fnsyn.2016.00032

Full-text PDF (final published version)
This is the final published version of the article (version of record). It first appeared online via Frontiers Media at http://dx.doi.org/10.3389/fnsyn.2016.00032. Please refer to any applicable terms of use of the publisher.
Final published version, 503 KBLicence: CC BY

Handle.net

Persistent link

Regulation of spine Ca2+ dynamics and spike timing-dependent synaptic plasticity by muscarinic acetylcholine receptors
Mellor, J. R.
1/10/12 → 1/10/15
Project: Research

Cite this

@article{7b20082c3aac461599c64ac5ab1b39b2,

title = "Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit",

abstract = "The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.",

keywords = "acetylcholine, noradrenaline, Serotonin, dopamine, dentate gyrus, CA3 , hippocampal, mossy fibers, computational modeling",

author = "Luke Prince and Bacon, {Travis J} and Cezar Tigaret and Jack Mellor",

note = "20 September 2016",

year = "2016",

month = oct,

day = "17",

doi = "10.3389/fnsyn.2016.00032",

language = "English",

volume = "8",

journal = "Frontiers in Synaptic Neuroscience",

issn = "1663-3563",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit

AU - Prince, Luke

AU - Bacon, Travis J

AU - Tigaret, Cezar

AU - Mellor, Jack

N1 - 20 September 2016

PY - 2016/10/17

Y1 - 2016/10/17

N2 - The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.

AB - The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.

KW - acetylcholine

KW - noradrenaline

KW - Serotonin

KW - dopamine

KW - dentate gyrus

KW - CA3

KW - hippocampal

KW - mossy fibers

KW - computational modeling

U2 - 10.3389/fnsyn.2016.00032

DO - 10.3389/fnsyn.2016.00032

M3 - Article (Academic Journal)

C2 - 27799909

SN - 1663-3563

VL - 8

JO - Frontiers in Synaptic Neuroscience

JF - Frontiers in Synaptic Neuroscience

M1 - 32

ER -

Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit

Abstract

Bibliographical note

Keywords

Access to Document

Handle.net

Fingerprint

Projects

Regulation of spine Ca2+ dynamics and spike timing-dependent synaptic plasticity by muscarinic acetylcholine receptors

Cite this