Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit

Luke Prince, Travis J Bacon, Cezar Tigaret, Jack Mellor

Research output: Contribution to journalArticle (Academic Journal)peer-review

15 Citations (Scopus)
298 Downloads (Pure)


The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.
Original languageEnglish
Article number32
Number of pages16
JournalFrontiers in Synaptic Neuroscience
Publication statusPublished - 17 Oct 2016

Bibliographical note

20 September 2016


  • acetylcholine
  • noradrenaline
  • Serotonin
  • dopamine
  • dentate gyrus
  • CA3
  • hippocampal
  • mossy fibers
  • computational modeling

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