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Neuronal Activity and Synaptic Plasticity Underlying Hippocampal Memory Engram

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

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Neuronal Activity and Synaptic Plasticity Underlying Hippocampal Memory Engram. / Tomar, Anupratap; Krishnan, Lalitha.

Synaptic Plasticity: Roles, Research and Insights. Nova Science Publishers, 2018. p. 225-250.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Harvard

Tomar, A & Krishnan, L 2018, Neuronal Activity and Synaptic Plasticity Underlying Hippocampal Memory Engram. in Synaptic Plasticity: Roles, Research and Insights. Nova Science Publishers, pp. 225-250.

APA

Tomar, A., & Krishnan, L. (2018). Neuronal Activity and Synaptic Plasticity Underlying Hippocampal Memory Engram. In Synaptic Plasticity: Roles, Research and Insights (pp. 225-250). Nova Science Publishers.

Vancouver

Tomar A, Krishnan L. Neuronal Activity and Synaptic Plasticity Underlying Hippocampal Memory Engram. In Synaptic Plasticity: Roles, Research and Insights. Nova Science Publishers. 2018. p. 225-250

Author

Tomar, Anupratap ; Krishnan, Lalitha. / Neuronal Activity and Synaptic Plasticity Underlying Hippocampal Memory Engram. Synaptic Plasticity: Roles, Research and Insights. Nova Science Publishers, 2018. pp. 225-250

Bibtex

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title = "Neuronal Activity and Synaptic Plasticity Underlying Hippocampal Memory Engram",
abstract = "Activity dependent synaptic plasticity is considered to be the physiological mechanism underlying learning and memory. Since the discovery of long-term potentiation (LTP) in 1973 by Bliss and Lomo, the popularity of synaptic plasticity has grown immensely. By October 2016, more than 51,000 research articles and reviews were indexed by PubMed. Recent emergence of optogenetics and chemogenetics has enabled researchers to generate neuronal activity patterns with precise temporal and spatial control in awake animals and brain slices. The relative ease of combining these tools with traditional electrophysiology will further expand the scope of synaptic plasticity research in freely behaving animals while they engage in cognition and memory tasks. This chapter aims to provide an overview of recent advances in the field of synaptic plasticity and learning and memory with a focus on cognitive impairments caused by stress-induced maladaptive synaptic plasticity. We summarize the latest memory engram data that claims to specifically manipulate the activity of hippocampal memory cells by employing optogenetics and DREADD chemogenetics. We end by discussing the potential consequences of long term usage of circuit genetic tools on neuronal network dynamics.",
keywords = "Synaptic plasticity",
author = "Anupratap Tomar and Lalitha Krishnan",
year = "2018",
month = "6",
language = "English",
pages = "225--250",
booktitle = "Synaptic Plasticity",
publisher = "Nova Science Publishers",

}

RIS - suitable for import to EndNote

TY - CHAP

T1 - Neuronal Activity and Synaptic Plasticity Underlying Hippocampal Memory Engram

AU - Tomar, Anupratap

AU - Krishnan, Lalitha

PY - 2018/6

Y1 - 2018/6

N2 - Activity dependent synaptic plasticity is considered to be the physiological mechanism underlying learning and memory. Since the discovery of long-term potentiation (LTP) in 1973 by Bliss and Lomo, the popularity of synaptic plasticity has grown immensely. By October 2016, more than 51,000 research articles and reviews were indexed by PubMed. Recent emergence of optogenetics and chemogenetics has enabled researchers to generate neuronal activity patterns with precise temporal and spatial control in awake animals and brain slices. The relative ease of combining these tools with traditional electrophysiology will further expand the scope of synaptic plasticity research in freely behaving animals while they engage in cognition and memory tasks. This chapter aims to provide an overview of recent advances in the field of synaptic plasticity and learning and memory with a focus on cognitive impairments caused by stress-induced maladaptive synaptic plasticity. We summarize the latest memory engram data that claims to specifically manipulate the activity of hippocampal memory cells by employing optogenetics and DREADD chemogenetics. We end by discussing the potential consequences of long term usage of circuit genetic tools on neuronal network dynamics.

AB - Activity dependent synaptic plasticity is considered to be the physiological mechanism underlying learning and memory. Since the discovery of long-term potentiation (LTP) in 1973 by Bliss and Lomo, the popularity of synaptic plasticity has grown immensely. By October 2016, more than 51,000 research articles and reviews were indexed by PubMed. Recent emergence of optogenetics and chemogenetics has enabled researchers to generate neuronal activity patterns with precise temporal and spatial control in awake animals and brain slices. The relative ease of combining these tools with traditional electrophysiology will further expand the scope of synaptic plasticity research in freely behaving animals while they engage in cognition and memory tasks. This chapter aims to provide an overview of recent advances in the field of synaptic plasticity and learning and memory with a focus on cognitive impairments caused by stress-induced maladaptive synaptic plasticity. We summarize the latest memory engram data that claims to specifically manipulate the activity of hippocampal memory cells by employing optogenetics and DREADD chemogenetics. We end by discussing the potential consequences of long term usage of circuit genetic tools on neuronal network dynamics.

KW - Synaptic plasticity

M3 - Chapter in a book

SP - 225

EP - 250

BT - Synaptic Plasticity

PB - Nova Science Publishers

ER -