Neuronal expression of muskelin in the rodent central nervous system

Nadia Tagnaouti, Sven Loebrich, Frank Heisler, Yvonne Pechmann, Susanne Fehr, Adèle De Arcangelis, Elisabeth Georges-Labouesse, Josephine C Adams, Matthias Kneussel

Research output: Contribution to journalArticle (Academic Journal)peer-review

17 Citations (Scopus)


The kelch repeat protein muskelin mediates cytoskeletal responses to the extracellular matrix protein thrombospondin 1, (TSP1), that is known to promote synaptogenesis in the central nervous system (CNS). Muskelin displays intracellular localization and affects cytoskeletal organization in adherent cells. Muskelin is expressed in adult brain and has been reported to bind the Cdk5 activator p39, which also facilitates the formation of functional synapses. Since little is known about muskelin in neuronal tissues, we here analysed the tissue distribution of muskelin in rodent brain and analysed its subcellular localization using cultured neurons from multiple life stages.
Original languageEnglish
Pages (from-to)28
JournalBMC Neuroscience
Publication statusPublished - 2007


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