Neuroprotective potential of astroglia

Beihui Liu, A. G. Teschemacher, Sergey Kasparov*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

29 Citations (Scopus)
283 Downloads (Pure)

Abstract

Astroglia are the homoeostatic cells of the central nervous system, which participate in all essential functions of the brain. Astrocytes support neuronal networks by handling water and ion fluxes, transmitter clearance, provision of antioxidants, and metabolic precursors and growth factors. The critical dependence of neurons on constant support from the astrocytes confers astrocytes with intrinsic neuroprotective properties. On the other hand, loss of astrocytic support or their pathological transformation compromises neuronal functionality and viability. Manipulating neuroprotective functions of astrocytes is thus an important strategy to enhance neuronal survival and improve outcomes in disease states.

Original languageEnglish
Pages (from-to)2126-2139
Number of pages14
JournalJournal of Neuroscience Research
Volume95
Issue number11
Early online date24 Aug 2017
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • astrocytes
  • homeostasis
  • neurodegeneration
  • neurodegenerative diseases
  • neurons
  • neuroprotection

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