Neutrophil function: from mechanisms to disease

Borko Amulic, Christel Cazalet, Garret L Hayes, Kathleen D Metzler, Arturo Zychlinsky

Research output: Contribution to journalReview article (Academic Journal)

770 Citations (Scopus)

Abstract

Neutrophils are the most abundant white blood cells in circulation, and patients with congenital neutrophil deficiencies suffer from severe infections that are often fatal, underscoring the importance of these cells in immune defense. In spite of neutrophils' relevance in immunity, research on these cells has been hampered by their experimentally intractable nature. Here, we present a survey of basic neutrophil biology, with an emphasis on examples that highlight the function of neutrophils not only as professional killers, but also as instructors of the immune system in the context of infection and inflammatory disease. We focus on emerging issues in the field of neutrophil biology, address questions in this area that remain unanswered, and critically examine the experimental basis for common assumptions found in neutrophil literature.

Original languageEnglish
Pages (from-to)459-89
Number of pages31
JournalAnnual Review of Immunology
Volume30
DOIs
Publication statusPublished - 2012

Keywords

  • Animals
  • Autoimmune Diseases
  • Cell Communication
  • Humans
  • Immune System
  • Infection
  • Inflammation
  • Neoplasms
  • Neutrophil Activation
  • Neutrophils
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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