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Synthetic lectins are molecules designed for the challenging task of biomimetic carbohydrate recognition in water. Previous work has explored a family of such systems based on bi/terphenyl units as hydrophobic surfaces and isophthalamide spacers to provide polar binding groups. Here we report a related receptor which employs a new spacer, 2,5-bis-(aminomethyl)-pyrrole, with an alternative (A-D-A) set of H-bonding valencies. The modified spacer leads to significant changes in binding selectivity, including a preference for glucose over all other tested substrates.
|Number of pages||4|
|Journal||Organic and Biomolecular Chemistry|
|Publication status||Published - 2012|
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- 1 Finished
SYNTHETIC LECTIS FOR OLIGOSACCHARIDE BINDING IN AQUEOUS MEDIA
1/06/06 → 1/08/09