New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Yingchang Lu; Felix R Day; Stefan Gustafsson; Martin L Buchkovich; Jianbo Na; Veronique Bataille; Diana L Cousminer; Zari Dastani; Alexander W Drong; Tõnu Esko; David M Evans; Mario Falchi; Mary F Feitosa; Teresa Ferreira; Åsa K Hedman; Robin Haring; Pirro G Hysi; Mark M Iles; Anne E Justice; Stavroula Kanoni; Vasiliki Lagou; Rui Li; Xin Li; Adam Locke; Chen Lu; Reedik Mägi; John R B Perry; Tune H Pers; Qibin Qi; Marianna Sanna; Ellen M Schmidt; William R Scott; Dmitry Shungin; Alexander Teumer; Anna A E Vinkhuyzen; Ryan W Walker; Harm-Jan Westra; Mingfeng Zhang; Weihua Zhang; Jing Hua Zhao; Zhihong Zhu; Uzma Afzal; Tarunveer Singh Ahluwalia; Stephan J L Bakker; Claire Bellis; Amélie Bonnefond; Katja Borodulin; Aron S Buchman; Tommy Cederholm; Audrey C Choh; Hyung Jin Choi; Joanne E Curran; Lisette C P G M de Groot; Philip L De Jager; Rosalie A M Dhonukshe-Rutten; Anke W Enneman; Elodie Eury; Daniel S Evans; Tom Forsen; Nele Friedrich; Frédéric Fumeron; Melissa E Garcia; Simone Gärtner; Bok-Ghee Han; Aki S Havulinna; Caroline Hayward; Dena Hernandez; Hans Hillege; Till Ittermann; Jack W Kent; Ivana Kolcic; Tiina Laatikainen; Jari Lahti; Irene Mateo Leach; Christine G Lee; Jong-Young Lee; Tian Liu; Youfang Liu; Stéphane Lobbens; Marie Loh; Leo-Pekka Lyytikäinen; Carolina Medina-Gomez; Karl Michaëlsson; Mike A Nalls; Carrie M Nielson; Laticia Oozageer; Laura Pascoe; Lavinia Paternoster; Ozren Polašek; Samuli Ripatti; Mark A Sarzynski; Chan Soo Shin; Nina Smolej Narančić; Dominik Spira; Priya Srikanth; Elisabeth Steinhagen-Thiessen; Yun Ju Sung; Karin M A Swart; Leena Taittonen; Toshiko Tanaka; Emmi Tikkanen; Nathalie van der Velde; Natasja M van Schoor; Niek Verweij; Alan F Wright; Lei Yu; Joseph M Zmuda; Niina Eklund; Terrence Forrester; Niels Grarup; Anne U Jackson; Kati Kristiansson; Teemu Kuulasmaa; Johanna Kuusisto; Peter Lichtner; Jian'an Luan; Anubha Mahajan; Satu Männistö; Cameron D Palmer; Janina S Ried; Robert A Scott; Alena Stancáková; Peter J Wagner; Ayse Demirkan; Angela Döring; Vilmundur Gudnason; Douglas P Kiel; Brigitte Kühnel; Massimo Mangino; Barbara Mcknight; Cristina Menni; Jeffrey R O'Connell; Ben A Oostra; Alan R Shuldiner; Kijoung Song; Liesbeth Vandenput; Cornelia M van Duijn; Peter Vollenweider; Charles C White; Michael Boehnke; Yvonne Boettcher; Richard S Cooper; Nita G Forouhi; Christian Gieger; Harald Grallert; Aroon Hingorani; Torben Jørgensen; Pekka Jousilahti; Mika J Kivimaki; Meena Kumari; Markku Laakso; Claudia Langenberg; Allan Linneberg; Amy Luke; Colin A Mckenzie; Aarno Palotie; Oluf Pedersen; Annette Peters; Konstantin Strauch; Bamidele O Tayo; Nicholas J Wareham; David A Bennett; Lars Bertram; John Blangero; Matthias Blüher; Claude Bouchard; Harry Campbell; Nam H Cho; Steven R Cummings; Stefan A Czerwinski; Ilja Demuth; Rahel Eckardt; Johan G Eriksson; Luigi Ferrucci; Oscar H Franco; Philippe Froguel; Ron T Gansevoort; Torben Hansen; Tamara B Harris; Nicholas Hastie; Markku Heliövaara; Albert Hofman; Joanne M Jordan; Antti Jula; Mika Kähönen; Eero Kajantie; Paul B Knekt; Seppo Koskinen; Peter Kovacs; Terho Lehtimäki; Lars Lind; Yongmei Liu; Eric S Orwoll; Clive Osmond; Markus Perola; Louis Pérusse; Olli T Raitakari; Tuomo Rankinen; Dabeeru C Rao; Treva K Rice; Fernando Rivadeneira; Igor Rudan; Veikko Salomaa; Thorkild Sorensen; Michael Stumvoll; Anke Tönjes; Bradford Towne; Gregory J Tranah; Angelo Tremblay; André G Uitterlinden; Pim van der Harst; Erkki Vartiainen; Jorma S Viikari; Veronique Vitart; Marie-Claude Vohl; Henry Völzke; Mark Walker; Henri Wallaschofski; Sarah Wild; James F Wilson; Loïc Yengo; D Timothy Bishop; Ingrid B Borecki; John C Chambers; L Adrienne Cupples; Abbas Dehghan; Panos Deloukas; Ghazaleh Fatemifar; Caroline Fox; Terrence S Furey; Lude Franke; Jiali Han; David J Hunter; Juha Karjalainen; Fredrik Karpe; Robert C Kaplan; Jaspal S Kooner; Mark I McCarthy; Joanne M Murabito; Andrew P Morris; Julia A N Bishop; Kari E North; Claes Ohlsson; Ken K Ong; Inga Prokopenko; J Brent Richards; Eric E Schadt; Tim D Spector; Elisabeth Widén; Cristen J Willer; Jian Yang; Erik Ingelsson; Karen L Mohlke; Joel N Hirschhorn; John Andrew Pospisilik; M Carola Zillikens; Cecilia Lindgren; Tuomas Oskari Kilpeläinen; Ruth J F Loos

doi:10.1038/ncomms10495

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Yingchang Lu
, Felix R Day
, Stefan Gustafsson
, Martin L Buchkovich
, Jianbo Na
, Veronique Bataille
, Diana L Cousminer
, Zari Dastani
, Alexander W Drong
, Tõnu Esko
, David M Evans
, Mario Falchi
, Mary F Feitosa
, Teresa Ferreira
, Åsa K Hedman
, Robin Haring
, Pirro G Hysi
, Mark M Iles
, Anne E Justice
, Stavroula Kanoni

Vasiliki Lagou, Rui Li, Xin Li, Adam Locke, Chen Lu, Reedik Mägi, John R B Perry, Tune H Pers, Qibin Qi, Marianna Sanna, Ellen M Schmidt, William R Scott, Dmitry Shungin, Alexander Teumer, Anna A E Vinkhuyzen, Ryan W Walker, Harm-Jan Westra, Mingfeng Zhang, Weihua Zhang, Jing Hua Zhao, Zhihong Zhu, Uzma Afzal, Tarunveer Singh Ahluwalia, Stephan J L Bakker, Claire Bellis, Amélie Bonnefond, Katja Borodulin, Aron S Buchman, Tommy Cederholm, Audrey C Choh, Hyung Jin Choi, Joanne E Curran, Lisette C P G M de Groot, Philip L De Jager, Rosalie A M Dhonukshe-Rutten, Anke W Enneman, Elodie Eury, Daniel S Evans, Tom Forsen, Nele Friedrich, Frédéric Fumeron, Melissa E Garcia, Simone Gärtner, Bok-Ghee Han, Aki S Havulinna, Caroline Hayward, Dena Hernandez, Hans Hillege, Till Ittermann, Jack W Kent, Ivana Kolcic, Tiina Laatikainen, Jari Lahti, Irene Mateo Leach, Christine G Lee, Jong-Young Lee, Tian Liu, Youfang Liu, Stéphane Lobbens, Marie Loh, Leo-Pekka Lyytikäinen, Carolina Medina-Gomez, Karl Michaëlsson, Mike A Nalls, Carrie M Nielson, Laticia Oozageer, Laura Pascoe, Lavinia Paternoster, Ozren Polašek, Samuli Ripatti, Mark A Sarzynski, Chan Soo Shin, Nina Smolej Narančić, Dominik Spira, Priya Srikanth, Elisabeth Steinhagen-Thiessen, Yun Ju Sung, Karin M A Swart, Leena Taittonen, Toshiko Tanaka, Emmi Tikkanen, Nathalie van der Velde, Natasja M van Schoor, Niek Verweij, Alan F Wright, Lei Yu, Joseph M Zmuda, Niina Eklund, Terrence Forrester, Niels Grarup, Anne U Jackson, Kati Kristiansson, Teemu Kuulasmaa, Johanna Kuusisto, Peter Lichtner, Jian'an Luan, Anubha Mahajan, Satu Männistö, Cameron D Palmer, Janina S Ried, Robert A Scott, Alena Stancáková, Peter J Wagner, Ayse Demirkan, Angela Döring, Vilmundur Gudnason, Douglas P Kiel, Brigitte Kühnel, Massimo Mangino, Barbara Mcknight, Cristina Menni, Jeffrey R O'Connell, Ben A Oostra, Alan R Shuldiner, Kijoung Song, Liesbeth Vandenput, Cornelia M van Duijn, Peter Vollenweider, Charles C White, Michael Boehnke, Yvonne Boettcher, Richard S Cooper, Nita G Forouhi, Christian Gieger, Harald Grallert, Aroon Hingorani, Torben Jørgensen, Pekka Jousilahti, Mika J Kivimaki, Meena Kumari, Markku Laakso, Claudia Langenberg, Allan Linneberg, Amy Luke, Colin A Mckenzie, Aarno Palotie, Oluf Pedersen, Annette Peters, Konstantin Strauch, Bamidele O Tayo, Nicholas J Wareham, David A Bennett, Lars Bertram, John Blangero, Matthias Blüher, Claude Bouchard, Harry Campbell, Nam H Cho, Steven R Cummings, Stefan A Czerwinski, Ilja Demuth, Rahel Eckardt, Johan G Eriksson, Luigi Ferrucci, Oscar H Franco, Philippe Froguel, Ron T Gansevoort, Torben Hansen, Tamara B Harris, Nicholas Hastie, Markku Heliövaara, Albert Hofman, Joanne M Jordan, Antti Jula, Mika Kähönen, Eero Kajantie, Paul B Knekt, Seppo Koskinen, Peter Kovacs, Terho Lehtimäki, Lars Lind, Yongmei Liu, Eric S Orwoll, Clive Osmond, Markus Perola, Louis Pérusse, Olli T Raitakari, Tuomo Rankinen, Dabeeru C Rao, Treva K Rice, Fernando Rivadeneira, Igor Rudan, Veikko Salomaa, Thorkild Sorensen, Michael Stumvoll, Anke Tönjes, Bradford Towne, Gregory J Tranah, Angelo Tremblay, André G Uitterlinden, Pim van der Harst, Erkki Vartiainen, Jorma S Viikari, Veronique Vitart, Marie-Claude Vohl, Henry Völzke, Mark Walker, Henri Wallaschofski, Sarah Wild, James F Wilson, Loïc Yengo, D Timothy Bishop, Ingrid B Borecki, John C Chambers, L Adrienne Cupples, Abbas Dehghan, Panos Deloukas, Ghazaleh Fatemifar, Caroline Fox, Terrence S Furey, Lude Franke, Jiali Han, David J Hunter, Juha Karjalainen, Fredrik Karpe, Robert C Kaplan, Jaspal S Kooner, Mark I McCarthy, Joanne M Murabito, Andrew P Morris, Julia A N Bishop, Kari E North, Claes Ohlsson, Ken K Ong, Inga Prokopenko, J Brent Richards, Eric E Schadt, Tim D Spector, Elisabeth Widén, Cristen J Willer, Jian Yang, Erik Ingelsson, Karen L Mohlke, Joel N Hirschhorn, John Andrew Pospisilik, M Carola Zillikens, Cecilia Lindgren, Tuomas Oskari Kilpeläinen, Ruth J F Loos

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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440 Downloads (Pure)

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Original language	English
Article number	10495
Number of pages	15
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms10495
Publication status	Published - 1 Feb 2016

Keywords

Biological sciences
Genetics

Access to Document

10.1038/ncomms10495

ncomms10495
This is the final published version of the article (version of record). It first appeared online via Nature at http://www.nature.com/ncomms/2016/160201/ncomms10495/full/ncomms10495.html. Please refer to any applicable terms of use of the publisher.
Final published version, 1.95 MBLicence: CC BY

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MRC Population Health Scientist Fellowship
Paternoster, L. (Principal Investigator)
1/10/12 → 1/10/16
Project: Research

Professor Lavinia Paternoster
- lavinia.paternosterbristol.acuk
- Epidemiology and Health Data Science - Professor of Genetic Epidemiology
- Bristol Population Health Science Institute
- MRC Integrative Epidemiology Unit
Person: Academic , Member

Cite this

Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V., Cousminer, D. L., Dastani, Z., Drong, A. W., Esko, T., Evans, D. M., Falchi, M., Feitosa, M. F., Ferreira, T., Hedman, Å. K., Haring, R., Hysi, P. G., Iles, M. M., Justice, A. E., ... Loos, R. J. F. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7, Article 10495. https://doi.org/10.1038/ncomms10495

@article{5ee43311ff104af7aa9c6677117b865d,

title = "New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk",

abstract = "To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF\%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF\%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF\%. Seven loci showed a larger effect on BF\% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF\%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF\% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.",

keywords = "Biological sciences, Genetics",

author = "Yingchang Lu and Day, \{Felix R\} and Stefan Gustafsson and Buchkovich, \{Martin L\} and Jianbo Na and Veronique Bataille and Cousminer, \{Diana L\} and Zari Dastani and Drong, \{Alexander W\} and T{\~o}nu Esko and Evans, \{David M\} and Mario Falchi and Feitosa, \{Mary F\} and Teresa Ferreira and Hedman, \{{\AA}sa K\} and Robin Haring and Hysi, \{Pirro G\} and Iles, \{Mark M\} and Justice, \{Anne E\} and Stavroula Kanoni and Vasiliki Lagou and Rui Li and Xin Li and Adam Locke and Chen Lu and Reedik M{\"a}gi and Perry, \{John R B\} and Pers, \{Tune H\} and Qibin Qi and Marianna Sanna and Schmidt, \{Ellen M\} and Scott, \{William R\} and Dmitry Shungin and Alexander Teumer and Vinkhuyzen, \{Anna A E\} and Walker, \{Ryan W\} and Harm-Jan Westra and Mingfeng Zhang and Weihua Zhang and Zhao, \{Jing Hua\} and Zhihong Zhu and Uzma Afzal and Ahluwalia, \{Tarunveer Singh\} and Bakker, \{Stephan J L\} and Claire Bellis and Am{\'e}lie Bonnefond and Katja Borodulin and Buchman, \{Aron S\} and Tommy Cederholm and Choh, \{Audrey C\} and Choi, \{Hyung Jin\} and Curran, \{Joanne E\} and \{de Groot\}, \{Lisette C P G M\} and \{De Jager\}, \{Philip L\} and Dhonukshe-Rutten, \{Rosalie A M\} and Enneman, \{Anke W\} and Elodie Eury and Evans, \{Daniel S\} and Tom Forsen and Nele Friedrich and Fr{\'e}d{\'e}ric Fumeron and Garcia, \{Melissa E\} and Simone G{\"a}rtner and Bok-Ghee Han and Havulinna, \{Aki S\} and Caroline Hayward and Dena Hernandez and Hans Hillege and Till Ittermann and Kent, \{Jack W\} and Ivana Kolcic and Tiina Laatikainen and Jari Lahti and \{Mateo Leach\}, Irene and Lee, \{Christine G\} and Jong-Young Lee and Tian Liu and Youfang Liu and St{\'e}phane Lobbens and Marie Loh and Leo-Pekka Lyytik{\"a}inen and Carolina Medina-Gomez and Karl Micha{\"e}lsson and Nalls, \{Mike A\} and Nielson, \{Carrie M\} and Laticia Oozageer and Laura Pascoe and Lavinia Paternoster and Ozren Pola{\v s}ek and Samuli Ripatti and Sarzynski, \{Mark A\} and Shin, \{Chan Soo\} and Naran{\v c}i{\'c}, \{Nina Smolej\} and Dominik Spira and Priya Srikanth and Elisabeth Steinhagen-Thiessen and Sung, \{Yun Ju\} and Swart, \{Karin M A\} and Leena Taittonen and Toshiko Tanaka and Emmi Tikkanen and \{van der Velde\}, Nathalie and \{van Schoor\}, \{Natasja M\} and Niek Verweij and Wright, \{Alan F\} and Lei Yu and Zmuda, \{Joseph M\} and Niina Eklund and Terrence Forrester and Niels Grarup and Jackson, \{Anne U\} and Kati Kristiansson and Teemu Kuulasmaa and Johanna Kuusisto and Peter Lichtner and Jian'an Luan and Anubha Mahajan and Satu M{\"a}nnist{\"o} and Palmer, \{Cameron D\} and Ried, \{Janina S\} and Scott, \{Robert A\} and Alena Stanc{\'a}kov{\'a} and Wagner, \{Peter J\} and Ayse Demirkan and Angela D{\"o}ring and Vilmundur Gudnason and Kiel, \{Douglas P\} and Brigitte K{\"u}hnel and Massimo Mangino and Barbara Mcknight and Cristina Menni and O'Connell, \{Jeffrey R\} and Oostra, \{Ben A\} and Shuldiner, \{Alan R\} and Kijoung Song and Liesbeth Vandenput and \{van Duijn\}, \{Cornelia M\} and Peter Vollenweider and White, \{Charles C\} and Michael Boehnke and Yvonne Boettcher and Cooper, \{Richard S\} and Forouhi, \{Nita G\} and Christian Gieger and Harald Grallert and Aroon Hingorani and Torben J{\o}rgensen and Pekka Jousilahti and Kivimaki, \{Mika J\} and Meena Kumari and Markku Laakso and Claudia Langenberg and Allan Linneberg and Amy Luke and Mckenzie, \{Colin A\} and Aarno Palotie and Oluf Pedersen and Annette Peters and Konstantin Strauch and Tayo, \{Bamidele O\} and Wareham, \{Nicholas J\} and Bennett, \{David A\} and Lars Bertram and John Blangero and Matthias Bl{\"u}her and Claude Bouchard and Harry Campbell and Cho, \{Nam H\} and Cummings, \{Steven R\} and Czerwinski, \{Stefan A\} and Ilja Demuth and Rahel Eckardt and Eriksson, \{Johan G\} and Luigi Ferrucci and Franco, \{Oscar H\} and Philippe Froguel and Gansevoort, \{Ron T\} and Torben Hansen and Harris, \{Tamara B\} and Nicholas Hastie and Markku Heli{\"o}vaara and Albert Hofman and Jordan, \{Joanne M\} and Antti Jula and Mika K{\"a}h{\"o}nen and Eero Kajantie and Knekt, \{Paul B\} and Seppo Koskinen and Peter Kovacs and Terho Lehtim{\"a}ki and Lars Lind and Yongmei Liu and Orwoll, \{Eric S\} and Clive Osmond and Markus Perola and Louis P{\'e}russe and Raitakari, \{Olli T\} and Tuomo Rankinen and Rao, \{Dabeeru C\} and Rice, \{Treva K\} and Fernando Rivadeneira and Igor Rudan and Veikko Salomaa and Thorkild Sorensen and Michael Stumvoll and Anke T{\"o}njes and Bradford Towne and Tranah, \{Gregory J\} and Angelo Tremblay and Uitterlinden, \{Andr{\'e} G\} and \{van der Harst\}, Pim and Erkki Vartiainen and Viikari, \{Jorma S\} and Veronique Vitart and Marie-Claude Vohl and Henry V{\"o}lzke and Mark Walker and Henri Wallaschofski and Sarah Wild and Wilson, \{James F\} and Lo{\"i}c Yengo and Bishop, \{D Timothy\} and Borecki, \{Ingrid B\} and Chambers, \{John C\} and Cupples, \{L Adrienne\} and Abbas Dehghan and Panos Deloukas and Ghazaleh Fatemifar and Caroline Fox and Furey, \{Terrence S\} and Lude Franke and Jiali Han and Hunter, \{David J\} and Juha Karjalainen and Fredrik Karpe and Kaplan, \{Robert C\} and Kooner, \{Jaspal S\} and McCarthy, \{Mark I\} and Murabito, \{Joanne M\} and Morris, \{Andrew P\} and Bishop, \{Julia A N\} and North, \{Kari E\} and Claes Ohlsson and Ong, \{Ken K\} and Inga Prokopenko and Richards, \{J Brent\} and Schadt, \{Eric E\} and Spector, \{Tim D\} and Elisabeth Wid{\'e}n and Willer, \{Cristen J\} and Jian Yang and Erik Ingelsson and Mohlke, \{Karen L\} and Hirschhorn, \{Joel N\} and Pospisilik, \{John Andrew\} and Zillikens, \{M Carola\} and Cecilia Lindgren and Kilpel{\"a}inen, \{Tuomas Oskari\} and Loos, \{Ruth J F\}",

year = "2016",

month = feb,

day = "1",

doi = "10.1038/ncomms10495",

language = "English",

volume = "7",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

Lu, Y, Day, FR, Gustafsson, S, Buchkovich, ML, Na, J, Bataille, V, Cousminer, DL, Dastani, Z, Drong, AW, Esko, T, Evans, DM, Falchi, M, Feitosa, MF, Ferreira, T, Hedman, ÅK, Haring, R, Hysi, PG, Iles, MM, Justice, AE, Kanoni, S, Lagou, V, Li, R, Li, X, Locke, A, Lu, C, Mägi, R, Perry, JRB, Pers, TH, Qi, Q, Sanna, M, Schmidt, EM, Scott, WR, Shungin, D, Teumer, A, Vinkhuyzen, AAE, Walker, RW, Westra, H-J, Zhang, M, Zhang, W, Zhao, JH, Zhu, Z, Afzal, U, Ahluwalia, TS, Bakker, SJL, Bellis, C, Bonnefond, A, Borodulin, K, Buchman, AS, Cederholm, T, Choh, AC, Choi, HJ, Curran, JE, de Groot, LCPGM, De Jager, PL, Dhonukshe-Rutten, RAM, Enneman, AW, Eury, E, Evans, DS, Forsen, T, Friedrich, N, Fumeron, F, Garcia, ME, Gärtner, S, Han, B-G, Havulinna, AS, Hayward, C, Hernandez, D, Hillege, H, Ittermann, T, Kent, JW, Kolcic, I, Laatikainen, T, Lahti, J, Mateo Leach, I, Lee, CG, Lee, J-Y, Liu, T, Liu, Y, Lobbens, S, Loh, M, Lyytikäinen, L-P, Medina-Gomez, C, Michaëlsson, K, Nalls, MA, Nielson, CM, Oozageer, L, Pascoe, L, Paternoster, L, Polašek, O, Ripatti, S, Sarzynski, MA, Shin, CS, Narančić, NS, Spira, D, Srikanth, P, Steinhagen-Thiessen, E, Sung, YJ, Swart, KMA, Taittonen, L, Tanaka, T, Tikkanen, E, van der Velde, N, van Schoor, NM, Verweij, N, Wright, AF, Yu, L, Zmuda, JM, Eklund, N, Forrester, T, Grarup, N, Jackson, AU, Kristiansson, K, Kuulasmaa, T, Kuusisto, J, Lichtner, P, Luan, J, Mahajan, A, Männistö, S, Palmer, CD, Ried, JS, Scott, RA, Stancáková, A, Wagner, PJ, Demirkan, A, Döring, A, Gudnason, V, Kiel, DP, Kühnel, B, Mangino, M, Mcknight, B, Menni, C, O'Connell, JR, Oostra, BA, Shuldiner, AR, Song, K, Vandenput, L, van Duijn, CM, Vollenweider, P, White, CC, Boehnke, M, Boettcher, Y, Cooper, RS, Forouhi, NG, Gieger, C, Grallert, H, Hingorani, A, Jørgensen, T, Jousilahti, P, Kivimaki, MJ, Kumari, M, Laakso, M, Langenberg, C, Linneberg, A, Luke, A, Mckenzie, CA, Palotie, A, Pedersen, O, Peters, A, Strauch, K, Tayo, BO, Wareham, NJ, Bennett, DA, Bertram, L, Blangero, J, Blüher, M, Bouchard, C, Campbell, H, Cho, NH, Cummings, SR, Czerwinski, SA, Demuth, I, Eckardt, R, Eriksson, JG, Ferrucci, L, Franco, OH, Froguel, P, Gansevoort, RT, Hansen, T, Harris, TB, Hastie, N, Heliövaara, M, Hofman, A, Jordan, JM, Jula, A, Kähönen, M, Kajantie, E, Knekt, PB, Koskinen, S, Kovacs, P, Lehtimäki, T, Lind, L, Liu, Y, Orwoll, ES, Osmond, C, Perola, M, Pérusse, L, Raitakari, OT, Rankinen, T, Rao, DC, Rice, TK, Rivadeneira, F, Rudan, I, Salomaa, V, Sorensen, T, Stumvoll, M, Tönjes, A, Towne, B, Tranah, GJ, Tremblay, A, Uitterlinden, AG, van der Harst, P, Vartiainen, E, Viikari, JS, Vitart, V, Vohl, M-C, Völzke, H, Walker, M, Wallaschofski, H, Wild, S, Wilson, JF, Yengo, L, Bishop, DT, Borecki, IB, Chambers, JC, Cupples, LA, Dehghan, A, Deloukas, P, Fatemifar, G, Fox, C, Furey, TS, Franke, L, Han, J, Hunter, DJ, Karjalainen, J, Karpe, F, Kaplan, RC, Kooner, JS, McCarthy, MI, Murabito, JM, Morris, AP, Bishop, JAN, North, KE, Ohlsson, C, Ong, KK, Prokopenko, I, Richards, JB, Schadt, EE, Spector, TD, Widén, E, Willer, CJ, Yang, J, Ingelsson, E, Mohlke, KL, Hirschhorn, JN, Pospisilik, JA, Zillikens, MC, Lindgren, C, Kilpeläinen, TO & Loos, RJF 2016, 'New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk', Nature Communications, vol. 7, 10495. https://doi.org/10.1038/ncomms10495

TY - JOUR

T1 - New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

AU - Lu, Yingchang

AU - Day, Felix R

AU - Gustafsson, Stefan

AU - Buchkovich, Martin L

AU - Na, Jianbo

AU - Bataille, Veronique

AU - Cousminer, Diana L

AU - Dastani, Zari

AU - Drong, Alexander W

AU - Esko, Tõnu

AU - Evans, David M

AU - Falchi, Mario

AU - Feitosa, Mary F

AU - Ferreira, Teresa

AU - Hedman, Åsa K

AU - Haring, Robin

AU - Hysi, Pirro G

AU - Iles, Mark M

AU - Justice, Anne E

AU - Kanoni, Stavroula

AU - Lagou, Vasiliki

AU - Li, Rui

AU - Li, Xin

AU - Locke, Adam

AU - Lu, Chen

AU - Mägi, Reedik

AU - Perry, John R B

AU - Pers, Tune H

AU - Qi, Qibin

AU - Sanna, Marianna

AU - Schmidt, Ellen M

AU - Scott, William R

AU - Shungin, Dmitry

AU - Teumer, Alexander

AU - Vinkhuyzen, Anna A E

AU - Walker, Ryan W

AU - Westra, Harm-Jan

AU - Zhang, Mingfeng

AU - Zhang, Weihua

AU - Zhao, Jing Hua

AU - Zhu, Zhihong

AU - Afzal, Uzma

AU - Ahluwalia, Tarunveer Singh

AU - Bakker, Stephan J L

AU - Bellis, Claire

AU - Bonnefond, Amélie

AU - Borodulin, Katja

AU - Buchman, Aron S

AU - Cederholm, Tommy

AU - Choh, Audrey C

AU - Choi, Hyung Jin

AU - Curran, Joanne E

AU - de Groot, Lisette C P G M

AU - De Jager, Philip L

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AU - Lindgren, Cecilia

AU - Kilpeläinen, Tuomas Oskari

AU - Loos, Ruth J F

PY - 2016/2/1

Y1 - 2016/2/1

N2 - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

AB - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

KW - Biological sciences

KW - Genetics

U2 - 10.1038/ncomms10495

DO - 10.1038/ncomms10495

M3 - Article (Academic Journal)

C2 - 26833246

SN - 2041-1723

VL - 7

JO - Nature Communications

JF - Nature Communications

M1 - 10495

ER -

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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MRC Population Health Scientist Fellowship

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Professor Lavinia Paternoster

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