Next-generation nephrology: part 1—an aid for genetic and genomic testing in pediatric nephrology

Asheeta Gupta*, Kushani Jayasinghe, Amar Majmundar, Nina Mann, Rajiv Sinha, Matthew G. Sampson, Catherine Quinlan

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

1 Citation (Scopus)

Abstract

Genetic and genomic testing has transformed the practice of clinical nephrology. Yet nephrologists have identified genetic literacy and access to kidney genetic care models as critical barriers to utilising this technology in their practice. To accelerate the implementation of genomic medicine in clinical nephrology, we provide a two-part evidence-based educational review. This inaugural segment highlights the importance of genomic testing for kidney disease and the steps a nephrologist can take to understand and apply this technology to one’s own clinical practice. The second part delineates approaches to operationalising a kidney genetics service based on existing models, reported barriers, and the authors’ experiences in developing kidney clinic models for different settings. Graphical Abstract: A higher resolution version of the Graphical abstract is available as Supplementary information
Original languageEnglish
Pages (from-to)2759-2777
Number of pages19
JournalPediatric Nephrology
Volume40
Issue number9
Early online date13 Feb 2025
DOIs
Publication statusPublished - 1 Sept 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025.

Keywords

  • Genomics
  • Genetics
  • Chronic kidney disease
  • Utility

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