Nickel-catalysed substitutions of aryl tert-butyl sulfones with organometallic reagents: Synthesis of ortho-substituted unsymmetrical biaryls

Jonathan Clayden, J. Jonathan A Cooney, Marc Julia*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)

Abstract

In the presence of a catalytic amount of a nickel salt, aryl tert-butyl sulfones react with aryl Grignard reagents to give biaryls. This reaction is used in conjunction with the powerful ortho-lithiation-directing ability of aryl tert-butyl sulfonyl groups to make unsymmetrical ortho-substituted biaryls. In certain cases, the substitution of an aryl alkylsulfonyl group by an organometallic reagent is possible without a transition metal catalyst.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number1
DOIs
Publication statusPublished - 1995

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