TY - JOUR
T1 - Nickel-catalysed substitutions of aryl tert-butyl sulfones with organometallic reagents
T2 - Synthesis of ortho-substituted unsymmetrical biaryls
AU - Clayden, Jonathan
AU - Cooney, J. Jonathan A
AU - Julia, Marc
PY - 1995
Y1 - 1995
N2 - In the presence of a catalytic amount of a nickel salt, aryl tert-butyl sulfones react with aryl Grignard reagents to give biaryls. This reaction is used in conjunction with the powerful ortho-lithiation-directing ability of aryl tert-butyl sulfonyl groups to make unsymmetrical ortho-substituted biaryls. In certain cases, the substitution of an aryl alkylsulfonyl group by an organometallic reagent is possible without a transition metal catalyst.
AB - In the presence of a catalytic amount of a nickel salt, aryl tert-butyl sulfones react with aryl Grignard reagents to give biaryls. This reaction is used in conjunction with the powerful ortho-lithiation-directing ability of aryl tert-butyl sulfonyl groups to make unsymmetrical ortho-substituted biaryls. In certain cases, the substitution of an aryl alkylsulfonyl group by an organometallic reagent is possible without a transition metal catalyst.
UR - http://www.scopus.com/inward/record.url?scp=37049082999&partnerID=8YFLogxK
U2 - 10.1039/P19950000007
DO - 10.1039/P19950000007
M3 - Article (Academic Journal)
AN - SCOPUS:37049082999
SN - 0300-922X
SP - 7
EP - 14
JO - Journal of the Chemical Society, Perkin Transactions 1
JF - Journal of the Chemical Society, Perkin Transactions 1
IS - 1
ER -