Nitrogen doped titanium dioxide as an aesthetic antimicrobial filler in dental polymers

N. A. Ahmad Fauzi; Anthony J Ireland; Martyn Sherriff; H M H N Bandara; Bo Su

doi:10.1016/j.dental.2021.10.019

Nitrogen doped titanium dioxide as an aesthetic antimicrobial filler in dental polymers

N. A. Ahmad Fauzi
, Anthony J Ireland
, Martyn Sherriff
, H M H N Bandara
, Bo Su^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

22 Citations (Scopus)

181 Downloads (Pure)

Abstract

Objective:
To develop an aesthetic resin composite using a nitrogen-doped titanium dioxide (N-TiO2) filler that possesses antibacterial properties against Streptococcus mutans.

Methods:
N-TiO2 powder was manufactured by calcining commercial TiO2 with urea. Free radical release from the N-TiO2 powder under visible light irradiation was analysed using UV-Vis spectrophotometry. The N-TiO2 powder was incorporated into a dental resin and the photocatalytic activity assessed using a dye under both visible light and dark conditions. The metabolic activity of Streptococcus mutans grown on the N-TiO2/resin composite discs was quantified by XTT reduction assay to assess the antibacterial properties of the resin.

Results:
Doping nitrogen of TiO2 resulted in a band gap shift towards the visible light spectrum, which enabled the powder to release reactive oxygen species when exposed to visible light. When incorporated into a dental resin, the N-TiO2/resin composite still demonstrated sustained release of reactive oxygen species, maintaining its photocatalytic activity and showing an antibacterial effect towards Streptococcus mutans under visible light compared to dark conditions (P<0.05).

Significance:
N-TiO2 filled resin composite shows great promise as a potential aesthetic resin-based adhesive for orthodontic bonding.

Original language	English
Pages (from-to)	147-157
Number of pages	11
Journal	Dental Materials
Volume	38
Issue number	1
Early online date	24 Nov 2021
DOIs	https://doi.org/10.1016/j.dental.2021.10.019
Publication status	Published - 19 Jan 2022

Bibliographical note

Publisher Copyright:
© 2021 The Academy of Dental Materials

Keywords

Nitrogen doped titanium dioxide
Antibacterial
Dental adhesive
Orthodontics

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10.1016/j.dental.2021.10.019

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This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.dental.2021.10.019. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 824 KBLicence: CC BY-NC-ND

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title = "Nitrogen doped titanium dioxide as an aesthetic antimicrobial filler in dental polymers",

abstract = "Objective: To develop an aesthetic resin composite using a nitrogen-doped titanium dioxide (N-TiO2) filler that possesses antibacterial properties against Streptococcus mutans. Methods: N-TiO2 powder was manufactured by calcining commercial TiO2 with urea. Free radical release from the N-TiO2 powder under visible light irradiation was analysed using UV-Vis spectrophotometry. The N-TiO2 powder was incorporated into a dental resin and the photocatalytic activity assessed using a dye under both visible light and dark conditions. The metabolic activity of Streptococcus mutans grown on the N-TiO2/resin composite discs was quantified by XTT reduction assay to assess the antibacterial properties of the resin. Results: Doping nitrogen of TiO2 resulted in a band gap shift towards the visible light spectrum, which enabled the powder to release reactive oxygen species when exposed to visible light. When incorporated into a dental resin, the N-TiO2/resin composite still demonstrated sustained release of reactive oxygen species, maintaining its photocatalytic activity and showing an antibacterial effect towards Streptococcus mutans under visible light compared to dark conditions (P<0.05). Significance: N-TiO2 filled resin composite shows great promise as a potential aesthetic resin-based adhesive for orthodontic bonding. ",

keywords = "Nitrogen doped titanium dioxide, Antibacterial, Dental adhesive, Orthodontics",

author = "\{Ahmad Fauzi\}, \{N. A.\} and Ireland, \{Anthony J\} and Martyn Sherriff and Bandara, \{H M H N\} and Bo Su",

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doi = "10.1016/j.dental.2021.10.019",

language = "English",

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T1 - Nitrogen doped titanium dioxide as an aesthetic antimicrobial filler in dental polymers

AU - Ahmad Fauzi, N. A.

AU - Ireland, Anthony J

AU - Sherriff, Martyn

AU - Bandara, H M H N

AU - Su, Bo

PY - 2022/1/19

Y1 - 2022/1/19

N2 - Objective: To develop an aesthetic resin composite using a nitrogen-doped titanium dioxide (N-TiO2) filler that possesses antibacterial properties against Streptococcus mutans. Methods: N-TiO2 powder was manufactured by calcining commercial TiO2 with urea. Free radical release from the N-TiO2 powder under visible light irradiation was analysed using UV-Vis spectrophotometry. The N-TiO2 powder was incorporated into a dental resin and the photocatalytic activity assessed using a dye under both visible light and dark conditions. The metabolic activity of Streptococcus mutans grown on the N-TiO2/resin composite discs was quantified by XTT reduction assay to assess the antibacterial properties of the resin. Results: Doping nitrogen of TiO2 resulted in a band gap shift towards the visible light spectrum, which enabled the powder to release reactive oxygen species when exposed to visible light. When incorporated into a dental resin, the N-TiO2/resin composite still demonstrated sustained release of reactive oxygen species, maintaining its photocatalytic activity and showing an antibacterial effect towards Streptococcus mutans under visible light compared to dark conditions (P<0.05). Significance: N-TiO2 filled resin composite shows great promise as a potential aesthetic resin-based adhesive for orthodontic bonding.

AB - Objective: To develop an aesthetic resin composite using a nitrogen-doped titanium dioxide (N-TiO2) filler that possesses antibacterial properties against Streptococcus mutans. Methods: N-TiO2 powder was manufactured by calcining commercial TiO2 with urea. Free radical release from the N-TiO2 powder under visible light irradiation was analysed using UV-Vis spectrophotometry. The N-TiO2 powder was incorporated into a dental resin and the photocatalytic activity assessed using a dye under both visible light and dark conditions. The metabolic activity of Streptococcus mutans grown on the N-TiO2/resin composite discs was quantified by XTT reduction assay to assess the antibacterial properties of the resin. Results: Doping nitrogen of TiO2 resulted in a band gap shift towards the visible light spectrum, which enabled the powder to release reactive oxygen species when exposed to visible light. When incorporated into a dental resin, the N-TiO2/resin composite still demonstrated sustained release of reactive oxygen species, maintaining its photocatalytic activity and showing an antibacterial effect towards Streptococcus mutans under visible light compared to dark conditions (P<0.05). Significance: N-TiO2 filled resin composite shows great promise as a potential aesthetic resin-based adhesive for orthodontic bonding.

KW - Nitrogen doped titanium dioxide

KW - Antibacterial

KW - Dental adhesive

KW - Orthodontics

U2 - 10.1016/j.dental.2021.10.019

DO - 10.1016/j.dental.2021.10.019

M3 - Article (Academic Journal)

C2 - 34836699

SN - 0109-5641

VL - 38

SP - 147

EP - 157

JO - Dental Materials

JF - Dental Materials

IS - 1

ER -

Nitrogen doped titanium dioxide as an aesthetic antimicrobial filler in dental polymers

Abstract

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Keywords

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