NKalpha: Non-uniform epistatic interactions in an extended NK model

Tom Hebbron, Seth Bullock, Dave Cliff

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Abstract

Kauffman’s seminal NK model was introduced to relate the properties of fitness landscapes to the extent and nature of epistasis between genes. The original model considered genomes in which the fitness contribution of each of N genes was influenced by the value of K other genes located either at random or from the immediately neighbouring loci on the genome. Both schemes ensure that (on average) every gene is as influential as any other. More recently, the epistatic connectivity between genes in natural genomes has begun to be mapped. The topologies of these genetic networks are neither random nor regular, but exhibit interesting structural properties. The model presented here extends the NK model to consider epistatic network topologies derived from a preferential attachment scheme which tends to ensure that some genes are more influential than others. We explore the consequences of this topology for the properties of the associated fitness landscapes.
Translated title of the contributionNKalpha: Non-uniform epistatic interactions in an extended NK model
Original languageEnglish
Title of host publicationArtificial Life XI
Subtitle of host publicationProceedings of the Eleventh International Conference on the Simulation and Synthesis of Living Systems
EditorsSeth Bullock, Jason Noble, Richard Watson, Mark A. Bedau
Place of PublicationCambridge, Massachusetts, USA
PublisherMassachusetts Institute of Technology (MIT) Press
Pages234-241
Number of pages8
ISBN (Print)9780262750172
Publication statusPublished - May 2008
EventEleventh International Conference on the Simulation and Synthesis of Living Systems - University of Southampton, Winchester, United Kingdom
Duration: 5 Aug 20088 Aug 2008

Conference

ConferenceEleventh International Conference on the Simulation and Synthesis of Living Systems
Country/TerritoryUnited Kingdom
CityWinchester
Period5/08/088/08/08

Bibliographical note

Conference Organiser: MIT Press

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