NMDARs in prefrontal cortex: Regulation of synaptic transmission and plasticity

Paul J Banks; Zafar I Bashir

doi:10.1016/j.neuropharm.2021.108614

NMDARs in prefrontal cortex: Regulation of synaptic transmission and plasticity

Paul J Banks, Zafar I Bashir^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

6 Citations (Scopus)

126 Downloads (Pure)

Abstract

In this review we consider the various roles played by N-methyl-d-aspartate receptors (NMDARs) located on pyramidal neurones in medial prefrontal cortex (mPFC). We focus on recent data from our lab that has investigated how NMDARs contribute to ongoing synaptic transmission in a frequency dependent manner, the plasticity of NMDARs and how this impacts their contribution to synaptic transmission, and finally consider how NMDARs contribute to plasticity induced by synchronous activation of two separate inputs to mPFC.

Original language	English
Article number	108614
Pages (from-to)	1-8
Journal	Neuropharmacology
Volume	192
DOIs	https://doi.org/10.1016/j.neuropharm.2021.108614
Publication status	Published - 20 May 2021

Bibliographical note

Keywords

prefrontal cortex
NMDA receptors
Synaptic plasticity
Learning and memory
Hippocampus
Nucleus reuniens

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10.1016/j.neuropharm.2021.108614

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This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.neuropharm.2021.108614. Please refer to any applicable terms of use of the publisher.
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title = "NMDARs in prefrontal cortex: Regulation of synaptic transmission and plasticity",

abstract = "In this review we consider the various roles played by N-methyl-d-aspartate receptors (NMDARs) located on pyramidal neurones in medial prefrontal cortex (mPFC). We focus on recent data from our lab that has investigated how NMDARs contribute to ongoing synaptic transmission in a frequency dependent manner, the plasticity of NMDARs and how this impacts their contribution to synaptic transmission, and finally consider how NMDARs contribute to plasticity induced by synchronous activation of two separate inputs to mPFC.",

keywords = "prefrontal cortex, NMDA receptors, Synaptic plasticity, Learning and memory, Hippocampus, Nucleus reuniens",

author = "Banks, {Paul J} and Bashir, {Zafar I}",

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doi = "10.1016/j.neuropharm.2021.108614",

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T2 - Regulation of synaptic transmission and plasticity

AU - Banks, Paul J

AU - Bashir, Zafar I

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N2 - In this review we consider the various roles played by N-methyl-d-aspartate receptors (NMDARs) located on pyramidal neurones in medial prefrontal cortex (mPFC). We focus on recent data from our lab that has investigated how NMDARs contribute to ongoing synaptic transmission in a frequency dependent manner, the plasticity of NMDARs and how this impacts their contribution to synaptic transmission, and finally consider how NMDARs contribute to plasticity induced by synchronous activation of two separate inputs to mPFC.

AB - In this review we consider the various roles played by N-methyl-d-aspartate receptors (NMDARs) located on pyramidal neurones in medial prefrontal cortex (mPFC). We focus on recent data from our lab that has investigated how NMDARs contribute to ongoing synaptic transmission in a frequency dependent manner, the plasticity of NMDARs and how this impacts their contribution to synaptic transmission, and finally consider how NMDARs contribute to plasticity induced by synchronous activation of two separate inputs to mPFC.

KW - prefrontal cortex

KW - NMDA receptors

KW - Synaptic plasticity

KW - Learning and memory

KW - Hippocampus

KW - Nucleus reuniens

U2 - 10.1016/j.neuropharm.2021.108614

DO - 10.1016/j.neuropharm.2021.108614

M3 - Review article (Academic Journal)

C2 - 34022178

SN - 0028-3908

VL - 192

SP - 1

EP - 8

JO - Neuropharmacology

JF - Neuropharmacology

M1 - 108614

ER -

NMDARs in prefrontal cortex: Regulation of synaptic transmission and plasticity

Abstract

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Keywords

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