NMDARs in prefrontal cortex: Regulation of synaptic transmission and plasticity

Paul J Banks, Zafar I Bashir*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

6 Citations (Scopus)
126 Downloads (Pure)

Abstract

In this review we consider the various roles played by N-methyl-d-aspartate receptors (NMDARs) located on pyramidal neurones in medial prefrontal cortex (mPFC). We focus on recent data from our lab that has investigated how NMDARs contribute to ongoing synaptic transmission in a frequency dependent manner, the plasticity of NMDARs and how this impacts their contribution to synaptic transmission, and finally consider how NMDARs contribute to plasticity induced by synchronous activation of two separate inputs to mPFC.

Original languageEnglish
Article number108614
Pages (from-to)1-8
JournalNeuropharmacology
Volume192
DOIs
Publication statusPublished - 20 May 2021

Bibliographical note

Copyright © 2021. Published by Elsevier Ltd.

Keywords

  • prefrontal cortex
  • NMDA receptors
  • Synaptic plasticity
  • Learning and memory
  • Hippocampus
  • Nucleus reuniens

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