Abstract
In this review we consider the various roles played by N-methyl-d-aspartate receptors (NMDARs) located on pyramidal neurones in medial prefrontal cortex (mPFC). We focus on recent data from our lab that has investigated how NMDARs contribute to ongoing synaptic transmission in a frequency dependent manner, the plasticity of NMDARs and how this impacts their contribution to synaptic transmission, and finally consider how NMDARs contribute to plasticity induced by synchronous activation of two separate inputs to mPFC.
Original language | English |
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Article number | 108614 |
Pages (from-to) | 1-8 |
Journal | Neuropharmacology |
Volume | 192 |
DOIs | |
Publication status | Published - 20 May 2021 |
Bibliographical note
Copyright © 2021. Published by Elsevier Ltd.Keywords
- prefrontal cortex
- NMDA receptors
- Synaptic plasticity
- Learning and memory
- Hippocampus
- Nucleus reuniens