No association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease

F Wavrant De-Vrieze, V Rudrasingham, JC Lambert, S Chakaverty, P Kehoe, R Crook, P Amouyel, W Wu, P Holmans, F Rice, J Perez-Tur, B Frigard, JC Morris, S Carty, D Cottel, N Tunstall, S Lovestone, RC Petersen, MC Chartier-Harlin, A GoateMJ Owen, J Williams, J Hardy

Research output: Contribution to journalArticle (Academic Journal)peer-review

36 Citations (Scopus)

Abstract

Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.
Translated title of the contributionNo association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease
Original languageEnglish
Pages (from-to)139 - 139
Number of pages1
JournalNeuroscience Letters
Volume262
DOIs
Publication statusPublished - Mar 1999

Bibliographical note

Publisher: Elsevier

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