No association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease

F Wavrant De-Vrieze, V Rudrasingham, JC Lambert, S Chakaverty, P Kehoe, R Crook, P Amouyel, W Wu, P Holmans, F Rice, J Perez-Tur, B Frigard, JC Morris, S Carty, D Cottel, N Tunstall, S Lovestone, RC Petersen, MC Chartier-Harlin, A GoateMJ Owen, J Williams, J Hardy

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Abstract

Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.
Translated title of the contributionNo association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease
Original languageEnglish
Pages (from-to)139 - 139
Number of pages1
JournalNeuroscience Letters
Volume262
DOIs
Publication statusPublished - Mar 1999

Bibliographical note

Publisher: Elsevier

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    Wavrant De-Vrieze, F., Rudrasingham, V., Lambert, JC., Chakaverty, S., Kehoe, P., Crook, R., Amouyel, P., Wu, W., Holmans, P., Rice, F., Perez-Tur, J., Frigard, B., Morris, JC., Carty, S., Cottel, D., Tunstall, N., Lovestone, S., Petersen, RC., Chartier-Harlin, MC., ... Hardy, J. (1999). No association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease. Neuroscience Letters, 262, 139 - 139. https://doi.org/10.1016/S0304-3940(99)00035-X