No association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease

F Wavrant De-Vrieze; V Rudrasingham; JC Lambert; S Chakaverty; P Kehoe; R Crook; P Amouyel; W Wu; P Holmans; F Rice; J Perez-Tur; B Frigard; JC Morris; S Carty; D Cottel; N Tunstall; S Lovestone; RC Petersen; MC Chartier-Harlin; A Goate; MJ Owen; J Williams; J Hardy

doi:10.1016/S0304-3940(99)00035-X

No association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease

F Wavrant De-Vrieze
, V Rudrasingham
, JC Lambert
, S Chakaverty
, P Kehoe
, R Crook
, P Amouyel
, W Wu
, P Holmans
, F Rice
, J Perez-Tur
, B Frigard
, JC Morris
, S Carty
, D Cottel
, N Tunstall
, S Lovestone
, RC Petersen
, MC Chartier-Harlin
, A Goate

MJ Owen, J Williams, J Hardy

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

41 Citations (Scopus)

Abstract

Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.

Translated title of the contribution	No association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease
Original language	English
Pages (from-to)	139 - 139
Number of pages	1
Journal	Neuroscience Letters
Volume	262
DOIs	https://doi.org/10.1016/S0304-3940(99)00035-X
Publication status	Published - Mar 1999

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Publisher: Elsevier

Research Groups and Themes

Cerebrovascular and Dementia Research Group

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Wavrant De-Vrieze, F., Rudrasingham, V., Lambert, JC., Chakaverty, S., Kehoe, P., Crook, R., Amouyel, P., Wu, W., Holmans, P., Rice, F., Perez-Tur, J., Frigard, B., Morris, JC., Carty, S., Cottel, D., Tunstall, N., Lovestone, S., Petersen, RC., Chartier-Harlin, MC., ... Hardy, J. (1999). No association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease. Neuroscience Letters, 262, 139 - 139. https://doi.org/10.1016/S0304-3940(99)00035-X

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title = "No association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease",

abstract = "Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.",

author = "\{Wavrant De-Vrieze\}, F and V Rudrasingham and JC Lambert and S Chakaverty and P Kehoe and R Crook and P Amouyel and W Wu and P Holmans and F Rice and J Perez-Tur and B Frigard and JC Morris and S Carty and D Cottel and N Tunstall and S Lovestone and RC Petersen and MC Chartier-Harlin and A Goate and MJ Owen and J Williams and J Hardy",

note = "Publisher: Elsevier",

year = "1999",

month = mar,

doi = "10.1016/S0304-3940(99)00035-X",

language = "English",

volume = "262",

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Wavrant De-Vrieze, F, Rudrasingham, V, Lambert, JC, Chakaverty, S, Kehoe, P, Crook, R, Amouyel, P, Wu, W, Holmans, P, Rice, F, Perez-Tur, J, Frigard, B, Morris, JC, Carty, S, Cottel, D, Tunstall, N, Lovestone, S, Petersen, RC, Chartier-Harlin, MC, Goate, A, Owen, MJ, Williams, J & Hardy, J 1999, 'No association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease', Neuroscience Letters, vol. 262, pp. 139 - 139. https://doi.org/10.1016/S0304-3940(99)00035-X

TY - JOUR

T1 - No association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease

AU - Wavrant De-Vrieze, F

AU - Rudrasingham, V

AU - Lambert, JC

AU - Chakaverty, S

AU - Kehoe, P

AU - Crook, R

AU - Amouyel, P

AU - Wu, W

AU - Holmans, P

AU - Rice, F

AU - Perez-Tur, J

AU - Frigard, B

AU - Morris, JC

AU - Carty, S

AU - Cottel, D

AU - Tunstall, N

AU - Lovestone, S

AU - Petersen, RC

AU - Chartier-Harlin, MC

AU - Goate, A

AU - Owen, MJ

AU - Williams, J

AU - Hardy, J

N1 - Publisher: Elsevier

PY - 1999/3

Y1 - 1999/3

N2 - Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.

AB - Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.

U2 - 10.1016/S0304-3940(99)00035-X

DO - 10.1016/S0304-3940(99)00035-X

M3 - Article (Academic Journal)

SN - 1872-7972

VL - 262

SP - 139

EP - 139

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

No association between the alpha-2 macroglobulin 11000V polymorphism and Alzheimer's disease

Abstract

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