TY - JOUR
T1 - No evidence for association between polymorphisms in GRM3 and schizophrenia
AU - Norton, Nadine
AU - Williams, Hywel
AU - Dwyer, Sarah
AU - Ivanov, Dobril
AU - Preece, Anna
AU - Gerrish, Amy
AU - Williams, Nigel Melville
AU - Yerassimou, P.
AU - Zammit, Stanley
AU - O'Donovan, Michael Conlon
AU - Owen, Michael John
PY - 2005/5/13
Y1 - 2005/5/13
N2 - BACKGROUND: Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3. METHODS: In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples. RESULTS: Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns. CONCLUSION: Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.
AB - BACKGROUND: Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3. METHODS: In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples. RESULTS: Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns. CONCLUSION: Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.
U2 - 10.1186/1471-244X-5-23
DO - 10.1186/1471-244X-5-23
M3 - Article (Academic Journal)
SN - 1471-244X
VL - 5
JO - BMC Psychiatry
JF - BMC Psychiatry
IS - 23
M1 - 23
ER -