No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes

Lisa M Maier, Juliet Chapman, Joanna M M Howson, David G Clayton, Rebecca Pask, David P Strachan, Wendy L McArdle, Rebecca C J Twells, John A Todd

Research output: Contribution to journalArticle (Academic Journal)peer-review

37 Citations (Scopus)

Abstract

Attempts to identify susceptibility loci that, on their own, have marginal main effects by use of gene-gene interaction tests have increased in popularity. The results obtained from analyses of epistasis are, however, difficult to interpret. Gene-gene interaction, albeit only marginally significant, has recently been reported for the interleukin-4 and interleukin-13 genes (IL4 and IL13) with the interleukin-4 receptor A gene (IL4RA), contributing to the susceptibility of type 1 diabetes (T1D). We aimed to replicate these findings by genotyping both large family and case-control data sets and by using previously published data. Gene-gene interaction tests were performed using linear regression models in cases only. We did not find any single-locus associations with T1D and did not obtain evidence of gene-gene interaction. Additional support from independent samples will be even more important in the study of gene-gene interactions and other subgroup analyses.
Original languageEnglish
Pages (from-to)517-21
Number of pages5
JournalAmerican Journal of Human Genetics
Volume76
Issue number3
DOIs
Publication statusPublished - 2005

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