No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

R Sims; S Dwyer; D Harold; A Gerrish; P Hollingworth; J Chapman; N Jones; R Abraham; D Ivanov; JS Pahwa; V Moskvina; K Dowzell; C Thomas; A Stretton; S Lovestone; J Powell; P Proitsi; MK Lupton; C Brayne; DC Rubinsztein; M Gill; B Lawler; A Lynch; K Morgan; KS Brown; PA Passmore; D Craig; B McGuiness; S Todd; JA Johnston; CH Holmes; D Mann; D Smith; S Love; PG Kehoe; J Hardy; S Mead; N Fox; M Rossor; J Collinge; G Livingston; NJ Bass; H Gurling; A McQuillin; L Jones; PA Holmans; M O'Donovan; MJ Owen; J Williams

doi:10.1002/ajmg.b.31216

No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

R Sims, S Dwyer, D Harold, A Gerrish, P Hollingworth, J Chapman, N Jones, R Abraham, D Ivanov, JS Pahwa, V Moskvina, K Dowzell, C Thomas, A Stretton, S Lovestone, J Powell, P Proitsi, MK Lupton, C Brayne, DC RubinszteinM Gill, B Lawler, A Lynch, K Morgan, KS Brown, PA Passmore, D Craig, B McGuiness, S Todd, JA Johnston, CH Holmes, D Mann, D Smith, S Love, PG Kehoe, J Hardy, S Mead, N Fox, M Rossor, J Collinge, G Livingston, NJ Bass, H Gurling, A McQuillin, L Jones, PA Holmans, M O'Donovan, MJ Owen, J Williams

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.

Translated title of the contribution	No evidence that extended tracts of homozygosity are associated with Alzheimer's disease
Original language	English
Pages (from-to)	764-71
Number of pages	8
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	156B
Issue number	7
DOIs	https://doi.org/10.1002/ajmg.b.31216
Publication status	Published - Dec 2011

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Cerebrovascular and Dementia Research Group

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Sims, R., Dwyer, S., Harold, D., Gerrish, A., Hollingworth, P., Chapman, J., Jones, N., Abraham, R., Ivanov, D., Pahwa, JS., Moskvina, V., Dowzell, K., Thomas, C., Stretton, A., Lovestone, S., Powell, J., Proitsi, P., Lupton, MK., Brayne, C., ... Williams, J. (2011). No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 156B(7), 764-71. https://doi.org/10.1002/ajmg.b.31216

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title = "No evidence that extended tracts of homozygosity are associated with Alzheimer's disease",

abstract = "We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.",

author = "R Sims and S Dwyer and D Harold and A Gerrish and P Hollingworth and J Chapman and N Jones and R Abraham and D Ivanov and JS Pahwa and V Moskvina and K Dowzell and C Thomas and A Stretton and S Lovestone and J Powell and P Proitsi and MK Lupton and C Brayne and DC Rubinsztein and M Gill and B Lawler and A Lynch and K Morgan and KS Brown and PA Passmore and D Craig and B McGuiness and S Todd and JA Johnston and CH Holmes and D Mann and D Smith and S Love and PG Kehoe and J Hardy and S Mead and N Fox and M Rossor and J Collinge and G Livingston and NJ Bass and H Gurling and A McQuillin and L Jones and PA Holmans and M O'Donovan and MJ Owen and J Williams",

note = "Copyright {\textcopyright} 2011 Wiley-Liss, Inc.",

year = "2011",

month = dec,

doi = "10.1002/ajmg.b.31216",

language = "English",

volume = "156B",

pages = "764--71",

journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",

issn = "1552-485X",

publisher = "Wiley",

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Sims, R, Dwyer, S, Harold, D, Gerrish, A, Hollingworth, P, Chapman, J, Jones, N, Abraham, R, Ivanov, D, Pahwa, JS, Moskvina, V, Dowzell, K, Thomas, C, Stretton, A, Lovestone, S, Powell, J, Proitsi, P, Lupton, MK, Brayne, C, Rubinsztein, DC, Gill, M, Lawler, B, Lynch, A, Morgan, K, Brown, KS, Passmore, PA, Craig, D, McGuiness, B, Todd, S, Johnston, JA, Holmes, CH, Mann, D, Smith, D, Love, S , Kehoe, PG, Hardy, J, Mead, S, Fox, N, Rossor, M, Collinge, J, Livingston, G, Bass, NJ, Gurling, H, McQuillin, A, Jones, L, Holmans, PA, O'Donovan, M, Owen, MJ & Williams, J 2011, 'No evidence that extended tracts of homozygosity are associated with Alzheimer's disease', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 156B, no. 7, pp. 764-71. https://doi.org/10.1002/ajmg.b.31216

TY - JOUR

T1 - No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

AU - Sims, R

AU - Dwyer, S

AU - Harold, D

AU - Gerrish, A

AU - Hollingworth, P

AU - Chapman, J

AU - Jones, N

AU - Abraham, R

AU - Ivanov, D

AU - Pahwa, JS

AU - Moskvina, V

AU - Dowzell, K

AU - Thomas, C

AU - Stretton, A

AU - Lovestone, S

AU - Powell, J

AU - Proitsi, P

AU - Lupton, MK

AU - Brayne, C

AU - Rubinsztein, DC

AU - Gill, M

AU - Lawler, B

AU - Lynch, A

AU - Morgan, K

AU - Brown, KS

AU - Passmore, PA

AU - Craig, D

AU - McGuiness, B

AU - Todd, S

AU - Johnston, JA

AU - Holmes, CH

AU - Mann, D

AU - Smith, D

AU - Love, S

AU - Kehoe, PG

AU - Hardy, J

AU - Mead, S

AU - Fox, N

AU - Rossor, M

AU - Collinge, J

AU - Livingston, G

AU - Bass, NJ

AU - Gurling, H

AU - McQuillin, A

AU - Jones, L

AU - Holmans, PA

AU - O'Donovan, M

AU - Owen, MJ

AU - Williams, J

PY - 2011/12

Y1 - 2011/12

N2 - We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.

AB - We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.

U2 - 10.1002/ajmg.b.31216

DO - 10.1002/ajmg.b.31216

M3 - Article (Academic Journal)

C2 - 21812096

SN - 1552-485X

VL - 156B

SP - 764

EP - 771

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

IS - 7

ER -

No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

Abstract

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