No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

R Sims, S Dwyer, D Harold, A Gerrish, P Hollingworth, J Chapman, N Jones, R Abraham, D Ivanov, JS Pahwa, V Moskvina, K Dowzell, C Thomas, A Stretton, S Lovestone, J Powell, P Proitsi, MK Lupton, C Brayne, DC RubinszteinM Gill, B Lawler, A Lynch, K Morgan, KS Brown, PA Passmore, D Craig, B McGuiness, S Todd, JA Johnston, CH Holmes, D Mann, D Smith, S Love, PG Kehoe, J Hardy, S Mead, N Fox, M Rossor, J Collinge, G Livingston, NJ Bass, H Gurling, A McQuillin, L Jones, PA Holmans, M O'Donovan, MJ Owen, J Williams

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Abstract

We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.
Translated title of the contributionNo evidence that extended tracts of homozygosity are associated with Alzheimer's disease
Original languageEnglish
Pages (from-to)764-71
Number of pages8
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume156B
Issue number7
DOIs
Publication statusPublished - Dec 2011

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    Sims, R., Dwyer, S., Harold, D., Gerrish, A., Hollingworth, P., Chapman, J., Jones, N., Abraham, R., Ivanov, D., Pahwa, JS., Moskvina, V., Dowzell, K., Thomas, C., Stretton, A., Lovestone, S., Powell, J., Proitsi, P., Lupton, MK., Brayne, C., ... Williams, J. (2011). No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 156B(7), 764-71. https://doi.org/10.1002/ajmg.b.31216